452342-37-9

452342-37-9 structure

Name: GW6604
Chemical Name: 2-phenyl-4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridine
CAS Number: 452342-37-9
Molecular Formula: C₁₉H₁₄N₄
Molecular Weight: 298.341
Catalog: Research Areas Metabolic Disease
Create Date: 2016-05-09 20:08:29
Modify Date: 2025-08-25 17:59:56
GW-6604 is an ALK5 inhibitor with an IC50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis[1].

Name	2-phenyl-4-(5-pyridin-2-yl-1H-pyrazol-4-yl)pyridine
Synonyms	Pyridine, 2-phenyl-4-[5-(2-pyridinyl)-1H-pyrazol-4-yl]- 2-phenyl-4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]pyridine gw-6604 2-Phenyl-4-[5-(2-pyridinyl)-1H-pyrazol-4-yl]pyridine unii-273g6sn31h

Description	GW-6604 is an ALK5 inhibitor with an IC50 value of 140 nM for inhibiting its autophosphorylation, and can be used in the study of liver fibrosis[1].
Related Catalog	Research Areas >> Metabolic Disease
In Vitro	GW-6604(0-10 μM, )抑制 HepG2 细胞中 TGF-β 诱导的 PAI-1 转录和分泌的 IC50 值为 500 nM，有效阻断了 Smad 依赖性反应[1]。
In Vivo	GW-6604(p.o., 25-80 mg/kg, twice a day, 3 weeks)在 SD 大鼠急性 DMN 模型中，依赖性地抑制肝脏 COL IA1 过度表达，使其表达降低了 80%。保持了正常的肝脏重量，有效减少了肝纤维化以及增加基质退化[1]。
References	[1]. Anne-Charlotte de Gouville, et al. Inhibition of TGF-beta signaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis. Br J Pharmacol. 2005 May;145(2):166-77.