1062605-69-9

1062605-69-9 structure

Name: Desvenlafaxine-d6
Chemical Name: 4-[2-{Bis[(2H3)methyl]amino}-1-(1-hydroxycyclohexyl)ethyl]phenol
CAS Number: 1062605-69-9
Molecular Formula: C₁₆H₁₉D₆NO₂
Molecular Weight: 269.41
Catalog: Signaling Pathways Neuronal Signaling Serotonin Transporter
Create Date: 2016-06-24 07:04:19
Modify Date: 2024-01-03 19:38:50
Desvenlafaxine-d6 is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].

Name	4-[2-{Bis[(2H3)methyl]amino}-1-(1-hydroxycyclohexyl)ethyl]phenol
Synonyms	d6-O-desmethylvenlafaxine 8\|A,9-Dihydroelymoclavine 8alpha,9-Dihydroelymoclavine trans-dihydrolysergol D,L-O-Desmethyl Venlafaxine-d6 d6-4-[2-dimethylamino-1-(1-hydroxycyclohexyl)-ethyl]-phenol dihydrolysergol 9,10-Dihydrolysergol \|A-Dihydrolysergol Dihydrolysergol I 6-Methyl-ergoline-8-methanol

Description	Desvenlafaxine-d6 is deuterium labeled Desvenlafaxine. Desvenlafaxine, the succinate salt form of the isolated major active metabolite of Venlafaxine (HY-B0196), is an orally active and BBB penetrated 5-HT and norepinephrine reuptake inhibitor, with IC50 values of 47.3 nM and 531.3 nM for hSERT and hNET, respectively. Desvenlafaxine shows weak binding affinity (62% inhibition at 100 μM) at the human dopamine (DA) transporter[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Deecher, D.C., et al., Desvenlafaxine succinate: A new serotonin and norepinephrine reuptake inhibitor. J Pharmacol Exp Ther, 2006. 318(2): p. 657-65. [3]. Sopko, M.A., Jr., M.J. Ehret, and M. Grgas, Desvenlafaxine: another "me too" drug? Ann Pharmacother, 2008. 42(10): p. 1439-46.

Symbol	GHS02, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H225-H301 + H311 + H331-H370
Precautionary Statements	P210-P260-P280-P301 + P310-P311
RIDADR	UN1230 - class 3 - PG 2 - Methanol, solution
Flash Point(F)	48.2 °F
Flash Point(C)	9 °C