186611-11-0

186611-11-0 structure

Name: SU5204
Chemical Name: (3E)-3-(2-Ethoxybenzylidene)-1,3-dihydro-2H-indol-2-one
CAS Number: 186611-11-0
Molecular Formula: C₁₇H₁₅NO₂
Molecular Weight: 265.30700
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2016-07-27 17:42:33
Modify Date: 2024-01-09 08:19:15
SU5204, a tyrosine kinase inhibitor extracted from patent US5792783A, has IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively[1].

Name	(3E)-3-(2-Ethoxybenzylidene)-1,3-dihydro-2H-indol-2-one
Synonyms	MFCD04651331

Description	SU5204, a tyrosine kinase inhibitor extracted from patent US5792783A, has IC50s of 4 and 51.5 μM for FLK-1 (VEGFR-2) and HER2, respectively[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
Target	VEGFR2:4 μM (IC50) HER2:51.5 μM (IC50)
References	[1]. Peng Cho Tang, et al. 3-heteroaryl-2-indolinone compounds for the treatment of disease. US5792783A.