80937-31-1
80937-31-1 structure
- Name: Flosulide
- Chemical Name: N-[6-(2,4-difluorophenoxy)-1-oxo-2,3-dihydroinden-5-yl]methanesulfonamide
- CAS Number: 80937-31-1
- Molecular Formula: C16H13F2NO4S
- Molecular Weight: 353.34100
- Catalog: Research Areas Inflammation/Immunology
- Create Date: 2018-05-16 08:00:00
- Modify Date: 2024-01-11 21:59:54
-
Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases.
| Name | N-[6-(2,4-difluorophenoxy)-1-oxo-2,3-dihydroinden-5-yl]methanesulfonamide |
|---|---|
| Synonyms |
n-[6-(2,4-difluorophenoxy)-1-oxo-2,3-dihydro-1h-inden-5-yl]methanesulfonamide
N-[6-(2,4-difluorophenoxy)-2,3-dihydro-1-oxo-1H-inden-5-yl]methanesulfonamide 6-(2,4-difluorophenoxy)-5-methylsulfonylamino-1-indanone 5-methanesulfonamido-6-((2,4-difluorophenyl)oxy)-1-indanone Flosulida [INN-Spanish] Flosulidum N-[6-(2,4-Difluoro-phenoxy)-1-oxo-indan-5-yl]-methanesulfonamide Flosulidum [INN-Latin] N-(6-(2,4-Difluorophenoxy)-1-oxo-5-indanyl)methanesulfonamide Flosulide Flosulida |
| Description | Flosulide is a potent and selective COX-2 inhibitor, used for the treatment for inflammatory diseases. |
|---|---|
| Related Catalog | |
| Target |
COX-2 |
| In Vitro | Flosulide (1 nM-100 μM) causes a concentration-dependent and finally complete inhibition of PGE2 production in the OSC-2 cell line, but with no effect on PG formation in the OSC-1 cells. Flosulide completely suppresses mitotic activity of OSC-2 cells, whereas mitotic activity of OSC-1 cells remain unchanged[2]. |
| In Vivo | In normovolemic rats, flosulide increases renal plasma flow (RPF) and and glomerular filtration rate (GFR). In hypovolemic rats, flosulide (5-25 mg/kg) reduces RPF and GFR. Flosulide at 5 mg/kg reduces 6-keto-PGF1alpha whereas at 25 mg/kg and after indomethacin at 10 mg/kg a fall in 6-keto-PGF1alpha and TXB2 appeares[1]. Flosulide (0.75 mg/day) significantly reduces proteinuria as compared to aspirin treatment. Plasma protein and albumin levels are significantly lower in the aspirin-treated group than in flosulide-treated rats[3]. |
| Cell Assay | The proliferation of the esophageal tumor cell lines is determined using the cell proliferation kit II. Tumor cells are incubated with flosulide and NS-398 at different concentrations for 48 h in DMEM containing FCS (10%), penicillin (100 units/mL), and streptomycin (0.1 mg/mL). After this time, the XTT labeling mixture is added, followed by 4 h of incubation and measurement of absorbance at 490 nm. |
| References |
| Density | 1.506g/cm3 |
|---|---|
| Boiling Point | 446.9ºC at 760 mmHg |
| Molecular Formula | C16H13F2NO4S |
| Molecular Weight | 353.34100 |
| Flash Point | 224.1ºC |
| Exact Mass | 353.05300 |
| PSA | 80.85000 |
| LogP | 4.41130 |
| Index of Refraction | 1.62 |
| Storage condition | 2-8℃ |