Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: guanoxabenz
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Purity: 98.0%
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24047-25-4

24047-25-4 structure

24047-25-4 structure

Name: Guanoxabenz
Chemical Name: 2-[(E)-(2,6-dichlorophenyl)methylideneamino]-1-hydroxyguanidine
CAS Number: 24047-25-4
Molecular Formula: C₈H₈Cl₂N₄O
Molecular Weight: 247.08100
Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
Create Date: 2018-07-04 19:16:41
Modify Date: 2024-01-05 00:50:20
Guanoxabenz is an α2 adrenergic receptor agonist.

Name	2-[(E)-(2,6-dichlorophenyl)methylideneamino]-1-hydroxyguanidine
Synonyms	UNII-P9HIK5V7WK Guanoxabenz Hydrazinecarboximidamide,2-((2,6-dichlorophenyl)methylene)-N-hydroxy Guanoxabenz (USAN/INN) 1-(2,6-dichlorobenzylideneamino)-3-hydroxyguanidine

Description	Guanoxabenz is an α2 adrenergic receptor agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor Research Areas >> Cardiovascular Disease
Target	Adrenergic receptor[1]
In Vitro	The formation of high-affinity Guanoxabenz binding seems to be inhibited by a series of N-hydroxyguanidine analogs to Guanoxabenz, as well as by a series of metabolic inhibitors that included allopurinol, 1-chloro-2,4-dinitrobenzene, 5,59-dithiobis-(2-nitrobenzoic acid), cibacron blue, phenyl-p-benzoquinone, didox, and trimidox. The formation of Guanoxabenz high-affinity binding is also inhibited in a time- and concentration-dependent fashion by preincubating the membranes with the LW03 N-hydroxyguanidine analogue of Guanoxabenz[1]. The spleen cytosolic fraction mediates the reduction of Guanoxabenz to guanabenz, the latter having an almost 100-fold higher affinity for rat alpha2A-adrenoceptors than Guanoxabenz itself[2].
In Vivo	Guanoxabenz and guanabenz are both known as centrally active antihypertensive drugs. enzymatic activity in the rat spleen can induce N-reduction of Guanoxabenz, leading to high affinity alphaα2 adrenergic receptor binding, due to the formation of theα2 adrenergic receptor active drug, guanabenz. High affinity Guanoxabenz binding is also induced in rat brain membranes after addition of NADH or NADPH cofactors. The rat cerebral cortex contains an enzymatic activity that may activate Guanoxabenz leading to formation of a metabolite showing high affinity for alpha 2-adrenoceptors[3].
References	[1]. Uhlén S, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at alpha2-adrenoceptors. I. Description of an enzymatic activity in spleen membranes. Biochem Pharmacol. 1998 Nov 1;56(9):1111-9. [2]. Dambrova M, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at alpha2-adrenoceptors. II. Description of a xanthine-dependent enzymatic activity in spleen cytosol. Biochem Pharmacol. 1998 Nov 1;56(9):1121-8. [3]. Dambrova M, et al. Characterization of Guanoxabenz reducing activity in rat brain. Pharmacol Toxicol. 1998 Oct;83(4):158-63.

Boiling Point	435.6ºC at 760mmHg
Molecular Formula	C₈H₈Cl₂N₄O
Molecular Weight	247.08100
Flash Point	217.2ºC
Exact Mass	246.00800
PSA	80.50000
LogP	2.71200
Storage condition	2-8℃