1024448-59-6
1024448-59-6 structure
- Name: RN 1747
- Chemical Name: 1-benzyl-4-(4-chloro-2-nitrophenyl)sulfonylpiperazine
- CAS Number: 1024448-59-6
- Molecular Formula: C17H18ClN3O4S
- Molecular Weight: 395.86
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2016-09-09 12:13:08
- Modify Date: 2024-01-02 17:44:13
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RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM[1].
| Name | 1-benzyl-4-(4-chloro-2-nitrophenyl)sulfonylpiperazine |
|---|---|
| Synonyms |
RN-1747
1-[(4-Chloro-2-nitrophenyl)sulfonyl]-4-(phenylmethyl)-piperazine 4-CHLORO-2-NITRO-1-((4-BENZYLPIPERAZINYL)SULFONYL)BENZENE 1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine |
| Description | RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
EC50: 0.77 μM (hTRPV4), 4.0 μM (mTRPV4), 4.1 μM (rTRPV4) [1]. |
| References |
| Molecular Formula | C17H18ClN3O4S |
|---|---|
| Molecular Weight | 395.86 |
| Exact Mass | 395.07100 |
| PSA | 94.82000 |
| LogP | 4.23450 |
| Storage condition | -20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933599090 |
| HS Code | 2933599090 |
|---|---|
| Summary | 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |