1346242-31-6

1346242-31-6 structure

Name: Rivastigmine carbamate impurity
Chemical Name: (3-nitrophenyl) N-ethyl-N-methylcarbamate
CAS Number: 1346242-31-6
Molecular Formula: C₁₀H₁₂N₂O₄
Molecular Weight: 224.21300
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2019-01-01 13:50:22
Modify Date: 2024-01-03 11:49:17
Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively[1][2].

Name	(3-nitrophenyl) N-ethyl-N-methylcarbamate
Synonyms	3-Nitrophenyl ethyl(methyl)carbamate Rivastigmine tartrate impurity,carbamate impurity-[USP] Carbamic acid,N-ethyl-N-methyl-,3-nitrophenyl ester UNII-5EM63X2EYP

Description	Rivastigmine carbamate impurity (3-Nitrophenyl ethyl(methyl)carbamate) is an impurity of Rivastigmine. Rivastigmine is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
References	[1]. Ziwei Chen, et al. Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease. Eur J Med Chem. 2017 Jan 5;125:784-792. [2]. Qian-Sheng Yu, et al. Anticholinesterase activity of compounds related to geneserine tautomers. N-Oxides and 1,2-oxazines. J Med Chem. 2002 Aug 15;45(17):3684-91.

Hazard Codes	Xi