30236-32-9
30236-32-9 structure
- Name: (+)-Sotalol
- Chemical Name: (+)-(s)-n-[4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide
- CAS Number: 30236-32-9
- Molecular Formula: C12H20N2O3S
- Molecular Weight: 272.36400
- Catalog: Signaling Pathways GPCR/G Protein Adrenergic Receptor
- Create Date: 2018-04-07 08:00:00
- Modify Date: 2025-08-27 13:30:49
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(+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3].
| Name | (+)-(s)-n-[4-[1-hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide |
|---|---|
| Synonyms |
Sotolol
Betacotdone d,l-sotalol SORBITOL |
| Description | (+)-Sotalol ((S)-Sotalol) is the S-isomer of Sotalol (HY-103196). Sotalol is an orally active, non-selective β-adrenergic receptor blocker. (+)-Sotalol is an antiarrhythmic agent. (+)-Sotalol can prolong action potential duration in isolated cardiac muscle[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
β-adrenoceptor |
| In Vitro | (+)-Sotalol (1, 10, 100 µM) 在离体心肌中增加动作电位持续时间[2]。 (+)-Sotalol (100 μM，60 分钟) 可延长三种细胞类型 (心内膜、心外膜、心肌中部和透壁细胞) 的动作电位[4]。 |
| In Vivo | (+)-Sotalol (8 mg/kg，静脉注射) 抑制程序刺激诱导的犬室性心动过速[3]。 Animal Model: Programmed stimulated Dogs[3] Dosage: 8 mg/kg Administration: Intravenous injection (i.v.) Result: Increased normal zone ventricular refractoriness, and prevented propagation of programmed ventricular extra-stimuli of sufficient prematurity to elicit tachyarrhythmias. |
| References |
| Density | 1.239g/cm3 |
|---|---|
| Boiling Point | 443.3ºC at 760mmHg |
| Molecular Formula | C12H20N2O3S |
| Molecular Weight | 272.36400 |
| Flash Point | 221.9ºC |
| Exact Mass | 272.11900 |
| PSA | 86.81000 |
| LogP | 2.63420 |
| Index of Refraction | 1.57 |