82079-32-1

82079-32-1 structure

Name: Thiolactomycin
Chemical Name: (2R)-5-hydroxy-2,4-dimethyl-2-[(1E)-2-methylbuta-1,3-dienyl]thiophen-3-one
CAS Number: 82079-32-1
Molecular Formula: C₁₁H₁₄O₂S
Molecular Weight: 210.29300
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-04-19 08:00:00
Modify Date: 2024-01-11 23:45:17
Thiolactomycin is an antibiotic. Thiolactomycin is active against Gram-negative anaerobes. Thiolactomycin also inhibits malaria and trypanosomes. Thiolactomycin is a FabB inhibitor. Thiolactomycin inhibits the synthesis of fatty acids and mycolic acids[1][2].

Name	(2R)-5-hydroxy-2,4-dimethyl-2-[(1E)-2-methylbuta-1,3-dienyl]thiophen-3-one
Synonyms	[R-(E)]-4-Hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone 2(5H)-Thiophenone,3,5-dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-,(R-(E)) Antibiotic 2-200 MFCD01940028 TLM (+)-Thiolactomycin (R,E)-4-hydroxy-3,5-dimethyl-5-(2-methylbuta-1,3-dienyl)thiophen-2(5H)-one (R-(E))-3,5-Dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone (5R)-4-hydroxy-3,5-dimethyl-5-(2-methyl-buta-1,3-dienyl)-5-H-thiophen-2-one (R)-(+)-Thiolactomycin 5R-Thiolactomycin

Description	Thiolactomycin is an antibiotic. Thiolactomycin is active against Gram-negative anaerobes. Thiolactomycin also inhibits malaria and trypanosomes. Thiolactomycin is a FabB inhibitor. Thiolactomycin inhibits the synthesis of fatty acids and mycolic acids[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Price AC, et al. Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J Biol Chem. 2001 Mar 2;276(9):6551-9. [2]. Slayden RA, et al. Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis. Antimicrob Agents Chemother. 1996 Dec;40(12):2813-9.

Precursor 2
497-03-0 241806-94-0
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