Thiolactomycin

Modify Date: 2024-01-11 23:45:17

Thiolactomycin Structure
Thiolactomycin structure
Common Name Thiolactomycin
CAS Number 82079-32-1 Molecular Weight 210.29300
Density 1.214g/cm3 Boiling Point 319.2ºC at 760 mmHg
Molecular Formula C11H14O2S Melting Point N/A
MSDS N/A Flash Point 146.8ºC

 Use of Thiolactomycin


Thiolactomycin is an antibiotic. Thiolactomycin is active against Gram-negative anaerobes. Thiolactomycin also inhibits malaria and trypanosomes. Thiolactomycin is a FabB inhibitor. Thiolactomycin inhibits the synthesis of fatty acids and mycolic acids[1][2].

 Names

Name (2R)-5-hydroxy-2,4-dimethyl-2-[(1E)-2-methylbuta-1,3-dienyl]thiophen-3-one
Synonym More Synonyms

 Thiolactomycin Biological Activity

Description Thiolactomycin is an antibiotic. Thiolactomycin is active against Gram-negative anaerobes. Thiolactomycin also inhibits malaria and trypanosomes. Thiolactomycin is a FabB inhibitor. Thiolactomycin inhibits the synthesis of fatty acids and mycolic acids[1][2].
Related Catalog
References

[1]. Price AC, et al. Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J Biol Chem. 2001 Mar 2;276(9):6551-9.  

[2]. Slayden RA, et al. Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis. Antimicrob Agents Chemother. 1996 Dec;40(12):2813-9.  

 Chemical & Physical Properties

Density 1.214g/cm3
Boiling Point 319.2ºC at 760 mmHg
Molecular Formula C11H14O2S
Molecular Weight 210.29300
Flash Point 146.8ºC
Exact Mass 210.07100
PSA 62.60000
LogP 2.98280
Index of Refraction 1.632

 Synthetic Route

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

[R-(E)]-4-Hydroxy-3,5-dimethyl-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone
2(5H)-Thiophenone,3,5-dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-,(R-(E))
Antibiotic 2-200
MFCD01940028
TLM
(+)-Thiolactomycin
(R,E)-4-hydroxy-3,5-dimethyl-5-(2-methylbuta-1,3-dienyl)thiophen-2(5H)-one
(R-(E))-3,5-Dimethyl-4-hydroxy-5-(2-methyl-1,3-butadienyl)-2(5H)-thiophenone
(5R)-4-hydroxy-3,5-dimethyl-5-(2-methyl-buta-1,3-dienyl)-5-H-thiophen-2-one
(R)-(+)-Thiolactomycin
5R-Thiolactomycin
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