75593-17-8

75593-17-8 structure

Name: Debromohymenialdisine
Chemical Name: (4Z)-4-(2-amino-4-oxo-1H-imidazol-5-ylidene)-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one
CAS Number: 75593-17-8
Molecular Formula: C₁₁H₁₁N₅O₂
Molecular Weight: 245.237
Catalog: Signaling Pathways MAPK/ERK Pathway MEK
Create Date: 2016-04-26 08:49:42
Modify Date: 2025-08-24 19:15:03
Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC50 value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation[1].

Name	(4Z)-4-(2-amino-4-oxo-1H-imidazol-5-ylidene)-1,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8-one
Synonyms	Pyrrolo[2,3-c]azepin-8(1H)-one, 4-(2-amino-3,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydro-, (4Z)- 2c3j (Z)-2-Debromohymenialdisine (4Z)-4-(2-Amino-5-oxo-1,5-dihydro-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydropyrrolo[2,3-c]azepin-8(1H)-one Debromohymenialdisine (Z)-Debromohymenialdisine debromohymenialdesine

Description	Debromohymenialdisine (10Z-Debromohymenialdisine) is a pyrrole alkaloid. Debromohymenialdisine has moderate inhibitory activity with an IC50 value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay. Debromohymenialdisine can be used for the research of proliferation and differentiation[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> MAPK/ERK Pathway >> MEK Signaling Pathways >> MAPK/ERK Pathway >> Raf
Target	IC50: 881 nM (in Raf/MEK-1/MAPK signaling cascade assay)[1].
In Vitro	Debromohymenialdisine has moderate inhibitory activity with an IC50 value of 881 nM in the initial Raf/MEK-1/MAPK signaling cascade assay[1].
References	[1]. Deniz Tasdemir, et al. Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1). J Med Chem. 2002 Jan 17;45(2):529-32.