4176-97-0

4176-97-0 structure

Name: 14-Deoxyandrographolide
Chemical Name: 3-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethy l-2-methylenedecahydro-1-naphthalenyl]ethyl}-2(5H)-furanone
CAS Number: 4176-97-0
Molecular Formula: C₂₀H₃₀O₄
Molecular Weight: 334.45000
Catalog: Research Areas Metabolic Disease
Create Date: 2018-02-13 08:00:00
Modify Date: 2024-01-11 22:26:18
14-Deoxyandrographolide, a bioactive compound of Andrographis paniculata, has hepatoprotective efficacy. 14-Deoxyandrographolide desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release[1].

Name	3-{2-[(1R,4aS,5R,6R,8aS)-6-Hydroxy-5-(hydroxymethyl)-5,8a-dimethy l-2-methylenedecahydro-1-naphthalenyl]ethyl}-2(5H)-furanone
Synonyms	20-ethyl-7,8-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)aconitan-14-one 14-Dehydro-browniin 14-Dehydrobrowniine Aconitan-14-one,20-ethyl-7,8-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-,(1alpha,6beta,16beta) 14-deoxy andrographolide Dehydrobrowniin 10-Dehydro-browniin 3-(2-((1R,4aS,5R,6R,8aS)-6-hydroxyl-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)ethyl)furan-2(5H)-one Deoxyandrographolide

Description	14-Deoxyandrographolide, a bioactive compound of Andrographis paniculata, has hepatoprotective efficacy. 14-Deoxyandrographolide desensitizes hepatocytes to TNF-α-mediated apoptosis through the release of TNFRSF1A release[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease
References	[1]. Roy DN, et al. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Br J Pharmacol. 2010 Aug;160(7):1823-43.

Density	1.15g/cm3
Boiling Point	509.5ºC at 760 mmHg
Melting Point	176-178ºC
Molecular Formula	C₂₀H₃₀O₄
Molecular Weight	334.45000
Flash Point	177.3ºC
Exact Mass	334.21400
PSA	66.76000
LogP	2.99180
Index of Refraction	1.551
Storage condition	2-8℃

496848-48-7

~82%

4176-97-0

Literature: Pandeti, Sukanya; Sonkar, Ravi; Shukla, Astha; Bhatia, Gitika; Tadigoppula, Narender European Journal of Medicinal Chemistry, 2013 , vol. 69, p. 439 - 448

142037-79-4

4176-97-0

Literature: Pal, Mahesh; Singh, Meenakshi; Sharma Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2002 , vol. 41, # 9 p. 1915 - 1918

82209-72-1

~2%

4176-97-0

Literature: Fujita, Tetsuro; Fujitani, Ryujiro; Takeda, Yoshio; Takaishi, Yoshihisa; Yamada, Toshihide; et al Chemical & Pharmaceutical Bulletin, 1984 , vol. 32, # 6 p. 2117 - 2125

Precursor 1
82209-72-1
DownStream 1
79233-15-1

4176-97-0	79233-15-1
86244-74-8	86244-69-1
124622-11-3	64812-05-1
75039-75-7	36311-34-9
35437-08-2	114076-71-0