873950-19-7
873950-19-7 structure
- Name: Atorvastatin Epoxy Tetrahydrofuran Impurity
- Chemical Name: 4-(4-fluorophenyl)-2,4-dihydroxy-N,5-diphenyl-2-propan-2-yl-3,6-dioxabicyclo[3.1.0]hexane-1-carboxamide
- CAS Number: 873950-19-7
- Molecular Formula: C26H24FNO5
- Molecular Weight: 449.47100
- Catalog: Research Areas Others
- Create Date: 2017-09-13 07:33:15
- Modify Date: 2024-01-03 09:19:45
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Atorvastatin Epoxy Tetrahydrofuran Impurity is an impurity isolated oxidative degradation products of Atorvastatin (HY-B0589)[1]. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids.
| Name | 4-(4-fluorophenyl)-2,4-dihydroxy-N,5-diphenyl-2-propan-2-yl-3,6-dioxabicyclo[3.1.0]hexane-1-carboxamide |
|---|---|
| Synonyms |
atorvastatin calcium epoxide dihydroxy
Atorvastatin Epoxy Tetrahydrofuran Impurity ATV-epoxy furan Atorvastatin Impurity 5 |
| Description | Atorvastatin Epoxy Tetrahydrofuran Impurity is an impurity isolated oxidative degradation products of Atorvastatin (HY-B0589)[1]. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids. |
|---|---|
| Related Catalog | |
| In Vitro | Atorvastatin treatment decreases apoptosis of myocardial cells by down-regulating GRP78, caspase-12 and CHOP expression in myocardial cells after myocardial infarction, and the endoplasmic reticulum (ER) stress is activated in response to heart failure and angiotensin II (Ang II) stimulation. |
| References |
| Molecular Formula | C26H24FNO5 |
|---|---|
| Molecular Weight | 449.47100 |
| Exact Mass | 449.16400 |
| PSA | 94.81000 |
| LogP | 4.29830 |
| Hazard Codes | Xi |
|---|
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~%
873950-19-7 |
| Literature: TEVA PHARMACEUTICAL INDUSTRIES LTD.; TEVA PHARMACEUTICALS USA, INC. Patent: WO2006/37125 A1, 2006 ; Location in patent: Page/Page column 17 ; |
