95523-13-0

95523-13-0 structure

Name: N-[(4-Aminophenyl)methyl]adenosine
Chemical Name: N-(2,3-dihydroxypropyl)-N-(2-hydroxyethyl)nitrous amide
CAS Number: 95523-13-0
Molecular Formula: C₁₇H₂₀N₆O₄
Molecular Weight: 372.38
Catalog: Signaling Pathways GPCR/G Protein Adenosine Receptor
Create Date: 2017-07-21 10:51:16
Modify Date: 2024-01-11 13:57:49
N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor inhibitor, with Ki of 29 nM for Rat ecto-5′-Nucleotidase.IC50 value: 29.0 ± 1.7 nM (Ki) Target: Adenosine Receptor

Name	N-(2,3-dihydroxypropyl)-N-(2-hydroxyethyl)nitrous amide
Synonyms	1,2-Propanediol,3-((2-hydroxyethyl)nitrosoamino) N-Nitroso-2,3-dihydroxypropyl-2-hydroxyethylamine 3-[(2-hydroxyethyl)(nitroso)amino]propane-1,2-diol N-Nitrosodihydroxypropylethanolamine N-Nitroso-2,3-dihydroxypropylethanolamine N6-(p-aminobenzyl)-adenosine Ndpea 3-((2-Hydroxyethyl)nitrosamino)-1,2-propanediol 1,2-Propanediol,3-((2-hydroxyethyl)nitrosamino) N6-(4-amino-benzyl)-adenosine [125I]-N6-(4-Aminobenzyl)adenosine N-[(4-Aminophenyl)methyl]adenosine

Description	N-[(4-Aminophenyl)methyl]adenosine is a adenosine receptor inhibitor, with Ki of 29 nM for Rat ecto-5′-Nucleotidase.IC50 value: 29.0 ± 1.7 nM (Ki) Target: Adenosine Receptor
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Neurological Disease
References	[1]. Bhattarai S, et al. α,β-Methylene-ADP (AOPCP) Derivatives and Analogues: Development of Potent and Selective ecto-5'-Nucleotidase (CD73) Inhibitors. J Med Chem. 2015 Aug 13;58(15):6248-63. [2]. Chen JB, et al. Design and synthesis of novel dual-action compounds targeting the adenosine A(2A) receptor and adenosine transporter for neuroprotection. ChemMedChem. 2011 Aug 1;6(8):1390-400. [3]. Zhu Z, et al. Constrained NBMPR analogue synthesis, pharmacophore mapping and 3D-QSAR modeling of equilibrative nucleoside transporter 1 (ENT1) inhibitory activity. Bioorg Med Chem. 2008 Apr 1;16(7):3848-65.

40297-54-9

~77%

95523-13-0

Literature: Robins; Asakura; Kaneko; Shibuya; Jakobs; Agbanyo; Cass; Paterson Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1627 - 1646

2004-06-0

140401-57-6

95523-13-0

Literature: INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES Patent: EP2511283 A1, 2012 ; Location in patent: Page/Page column 40 ;

112533-71-8

95523-13-0

Literature: Linden; Patel; Earl; Craig; Daluge Journal of medicinal chemistry, 1988 , vol. 31, # 4 p. 745 - 751

100-11-8

95523-13-0

Literature: Robins; Asakura; Kaneko; Shibuya; Jakobs; Agbanyo; Cass; Paterson Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1627 - 1646

58-61-7

95523-13-0

Literature: Robins; Asakura; Kaneko; Shibuya; Jakobs; Agbanyo; Cass; Paterson Nucleosides and Nucleotides, 1994 , vol. 13, # 6-7 p. 1627 - 1646

556-18-3

95523-13-0

Literature: INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES Patent: EP2511283 A1, 2012 ;

3419-18-9

95523-13-0

Literature: INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES Patent: EP2511283 A1, 2012 ;