204204-73-9

204204-73-9 structure

Name: R 138727
Chemical Name: 2-[1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-sulfanylpiperidin-3-ylidene]acetic acid
CAS Number: 204204-73-9
Molecular Formula: C₁₈H₂₀FNO₃S
Molecular Weight: 349.42
Catalog: Signaling Pathways GPCR/G Protein P2Y Receptor
Create Date: 2017-06-12 13:30:46
Modify Date: 2026-07-02 14:16:27
R-138727, the thiol-containing active metabolite of Prasugrel, is an irreversible platelet P2Y12 receptor inhibitor. R-138727 inhibits ADP-induced platelet aggregation[1].

Name	2-[1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-sulfanylpiperidin-3-ylidene]acetic acid
Synonyms	PRASUEL METABOLITE R-138727 R-138727 , CID Prasuel-d4 Metabolite R-138727 cis R-138727, (Prasuel Metabolite) (Mixture of Diastereomers) Discontinued Prasuel Metabolite -5 Prasuel metabolite R-13872 Prasuel Metabolite R Acetic acid, 2-[1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]-, (2Z) R-138727 (Prasuel Metabolite) R138727,R (2Z)-2-[1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-sulfanylpiperidin-3-ylidene]acetic acid cis R-138727, (Prasuel Metabolite) DISCONTINUED (Z)-2-(1-(2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-4-mercaptopiperidin-3-ylidene)acetic Acid Prasuel active metabolite (2Z)-{1-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-sulfanyl-3-piperidinylidene}acetic acid Prasuel Active Metabolite R138727 Prasuel Metabolite R-138727 HCl (Mixture of Diastereomers) (2Z)-2-[1-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]acetic acid R-138727

Description	R-138727, the thiol-containing active metabolite of Prasugrel, is an irreversible platelet P2Y12 receptor inhibitor. R-138727 inhibits ADP-induced platelet aggregation[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> P2Y Receptor
References	[1]. Hasegawa M, et al. Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor. Thromb Haemost. 2005 Sep;94(3):593-8.