R 138727

Modify Date: 2024-01-02 15:44:31

R 138727 Structure
R 138727 structure
Common Name R 138727
CAS Number 204204-73-9 Molecular Weight 349.42
Density 1.3±0.1 g/cm3 Boiling Point 513.4±50.0 °C at 760 mmHg
Molecular Formula C18H20FNO3S Melting Point N/A
MSDS N/A Flash Point 264.3±30.1 °C

 Use of R 138727


R-138727, the thiol-containing active metabolite of Prasugrel, is an irreversible platelet P2Y12 receptor inhibitor. R-138727 inhibits ADP-induced platelet aggregation[1].

 Names

Name 2-[1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-sulfanylpiperidin-3-ylidene]acetic acid
Synonym More Synonyms

 R 138727 Biological Activity

Description R-138727, the thiol-containing active metabolite of Prasugrel, is an irreversible platelet P2Y12 receptor inhibitor. R-138727 inhibits ADP-induced platelet aggregation[1].
Related Catalog
References

[1]. Hasegawa M, et al. Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor. Thromb Haemost. 2005 Sep;94(3):593-8.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 513.4±50.0 °C at 760 mmHg
Molecular Formula C18H20FNO3S
Molecular Weight 349.42
Flash Point 264.3±30.1 °C
Exact Mass 349.114807
PSA 96.41000
LogP 2.92
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.619

 Synonyms

(2Z)-{1-[2-Cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-sulfanyl-3-piperidinylidene}acetic acid
R 138727
Acetic acid, 2-[1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]-, (2Z)-
R-138727