874450-44-9
874450-44-9 structure
- Name: SEN 12333
- Chemical Name: 5-morpholin-4-yl-N-(4-pyridin-3-ylphenyl)pentanamide
- CAS Number: 874450-44-9
- Molecular Formula: C20H25N3O2
- Molecular Weight: 339.43100
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
- Create Date: 2017-04-27 22:09:59
- Modify Date: 2024-01-08 19:52:43
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SEN 12333 (WAY-317538) is a potent, selective and orally active α7 nAChR agonist. SEN12333 displays high affinity for the rat α7 nAChRs expressed in GH4C1 cells (K>i=260 nM) and acts as full agonist in functional Ca2+ flux studies (EC50=1.6 μM). SEN 12333 is used for AD and schizophrenia research[1].
| Name | 5-morpholin-4-yl-N-(4-pyridin-3-ylphenyl)pentanamide |
|---|---|
| Synonyms |
WAY-317,538
Carbazeran citrate |
| Description | SEN 12333 (WAY-317538) is a potent, selective and orally active α7 nAChR agonist. SEN12333 displays high affinity for the rat α7 nAChRs expressed in GH4C1 cells (K>i=260 nM) and acts as full agonist in functional Ca2+ flux studies (EC50=1.6 μM). SEN 12333 is used for AD and schizophrenia research[1]. |
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| Related Catalog | |
| In Vitro | In whole-cell patch-clamp recordings, SEN12333 activates peak currents and maximal total charges similar to acetylcholine (EC50= 12 μM). SEN12333 displays functional antagonism at histamine H3 receptors (IC50=103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50=8.5 μM)[1]. |
| In Vivo | SEN12333 (intraperitoneal injection; 3 mg/kg) improves episodic memory in a novel object recognition task in rats in conditions of spontaneous forgetting as well as cognitive disruptions induced via glutamatergic or cholinergic mechanisms. SEN12333 also prevents a scopolamine-induced deficit in a passive avoidance task[1]. |
| References |
| Molecular Formula | C20H25N3O2 |
|---|---|
| Molecular Weight | 339.43100 |
| Exact Mass | 339.19500 |
| PSA | 54.46000 |
| LogP | 3.20050 |
| Hazard Codes | Xn |
|---|