7246-14-2

7246-14-2 structure

Name: METHICILLIN SODIUM (500 MG) (AS)
Chemical Name: methicillin sodium monohydrate
CAS Number: 7246-14-2
Molecular Formula: C₁₇H₁₉N₂NaO₆S
Molecular Weight: 402.39700
Catalog: API Antibiotics Penicillin
Create Date: 2017-09-17 21:28:27
Modify Date: 2024-01-07 11:53:43
Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin sodium hydrate is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins. Methicillin sodium hydrate can be used for the research of skin infections, osteomyelitis, and endocarditis[1].

Name	methicillin sodium monohydrate
Synonyms	Sodium (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7- oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

Description	Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin sodium hydrate is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins. Methicillin sodium hydrate can be used for the research of skin infections, osteomyelitis, and endocarditis[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial Signaling Pathways >> GPCR/G Protein >> Histamine Receptor
In Vitro	Methcillin sodium hydrate (20 μg/mL, 24 h) results in a rapid decrease in CFU of S. aureus[2].
In Vivo	Methicillin sodium hydrate (Intramuscular administration, 40 mg/kg every 6 h, 5 days), in S. aureus.-infected rabbits[2].
References	[1]. Sharon S. Castle. Methicillin. xPharm: The Comprehensive Pharmacology Reference 2007, Pages 1-4. [2]. Jaime Carrizosa, et al. Treatment of Experimental Staphylococcus aureus Endocarditis: Comparison of Cephalothin, Cefazolin, and Methicillin. Antimicrob Agents Chemother. 1978 Jan; 13(1): 74–77.

RIDADR	NONH for all modes of transport