METHICILLIN SODIUM (500 MG) (AS)

Modify Date: 2025-08-27 20:31:59

METHICILLIN SODIUM (500 MG) (AS) Structure
METHICILLIN SODIUM (500 MG) (AS) structure
Common Name METHICILLIN SODIUM (500 MG) (AS)
CAS Number 7246-14-2 Molecular Weight 402.39700
Density N/A Boiling Point N/A
Molecular Formula C17H19N2NaO6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of METHICILLIN SODIUM (500 MG) (AS)


Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin sodium hydrate is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins. Methicillin sodium hydrate can be used for the research of skin infections, osteomyelitis, and endocarditis[1].

 Names

Name methicillin sodium monohydrate
Synonym More Synonyms

 METHICILLIN SODIUM (500 MG) (AS) Biological Activity

Description Methicillin sodium hydrate is a narrow-spectrum β-lactam antibiotic, acts by inhibiting penicillin-binding proteins (PBPs). Methicillin sodium hydrate is active against Staphylococcus aureus and Staphylococcus epidermidis that are resistant to other penicillins. Methicillin sodium hydrate can be used for the research of skin infections, osteomyelitis, and endocarditis[1].
Related Catalog
In Vitro Methcillin sodium hydrate (20 μg/mL, 24 h) results in a rapid decrease in CFU of S. aureus[2].
In Vivo Methicillin sodium hydrate (Intramuscular administration, 40 mg/kg every 6 h, 5 days), in S. aureus.-infected rabbits[2].
References

[1]. Sharon S. Castle. Methicillin. xPharm: The Comprehensive Pharmacology Reference 2007, Pages 1-4.

[2]. Jaime Carrizosa, et al. Treatment of Experimental Staphylococcus aureus Endocarditis: Comparison of Cephalothin, Cefazolin, and Methicillin. Antimicrob Agents Chemother. 1978 Jan; 13(1): 74–77.

 Chemical & Physical Properties

Molecular Formula C17H19N2NaO6S
Molecular Weight 402.39700
Exact Mass 402.08600
PSA 136.79000
LogP 1.33430
InChIKey NRZPASQBOYNGHR-HWROMZCQSA-M
SMILES COc1cccc(OC)c1C(=O)NC1C(=O)N2C1SC(C)(C)C2C(=O)[O-].O.[Na+]

 Safety Information

RIDADR NONH for all modes of transport

 METHICILLIN SODIUM (500 MG) (AS)Bioassay

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Name: Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Source: NCGC
External Id: SNCA-p-activity-luciferase
Name: p53 small molecule agonists, cell-based qHTS assay
Source: 824
External Id: P53344
Name: p53 small molecule agonists, cell-based qHTS assay with human liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS233
Name: p53 small molecule agonists, cell-based qHTS assay with rat liver microsomes
Source: 824
Target: tumor suppressor p53 [Homo sapiens]
External Id: P53MS898
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 Synonyms

Sodium (2S,5R,6R)-6-[(2,6-dimethoxybenzoyl)amino]-3,3-dimethyl-7- oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
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