546-78-1
546-78-1 structure
- Name: Umbellulone
- Chemical Name: umbellulone
- CAS Number: 546-78-1
- Molecular Formula: C10H14O
- Molecular Weight: 150.21800
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
- Create Date: 2016-04-24 11:23:45
- Modify Date: 2024-01-03 09:09:08
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Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism[1].
| Name | umbellulone |
|---|---|
| Synonyms | Thuj-3-en-2-on |
| Description | Umbellulone is an active constituent of the leaves of Umbellularia californica. Umbellulone stimulates the TRPA1 channel in a subset of peptidergic, nociceptive neurons, activating the trigeminovascular system via this mechanism[1]. |
|---|---|
| Related Catalog | |
| Target |
TRPA1 channel[1] |
| In Vitro | Umbellulone, from µM to sub-mM concentrations, selectively stimulates transient receptor potential ankyrin 1-expressing HEK293 cells[1]. |
| In Vivo | Umbellulone (50–250 nM/5ul) causes an acute nocioceptive response in a dose-dependent manner in Trpa1+/+ mice[1]. Umbellulone (150 µg/kg; intravenous or intranasal) do not affect systemic blood pressure[1]. Umbellulone (30-150 μg/kg; i.v.) increases meningeal blood flow in a dose-dependent manner[1]. Animal Model: Sprague-Dawley rats (male, 250 g)[1] Dosage: 30 μg/kg, 75 μg/kg, 150 μg/kg Administration: Intravenously Result: Increased meningeal blood flow in a dose-dependent manner. |
| References |
| Molecular Formula | C10H14O |
|---|---|
| Molecular Weight | 150.21800 |
| Exact Mass | 150.10400 |
| PSA | 17.07000 |
| LogP | 2.17770 |
| Storage condition | -20°C |
