26904-64-3

26904-64-3 structure

Name: Oxysophocarpine
Chemical Name: oxysophocarpine
CAS Number: 26904-64-3
Molecular Formula: C₁₅H₂₂N₂O₂
Molecular Weight: 262.347
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-07-23 11:45:09
Modify Date: 2024-01-02 08:38:40
Oxysophocarpine is an alkaloid extracted from Siphocampylus verticillatus. Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems[1]. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC)[2].

Name	oxysophocarpine
Synonyms	N-oxosophocarpine sophocarpidine (7aS,13aR,13bR,13cS)-2,3,6,7,7a,8,13,13a,13b,13c-Decahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one 4-oxide Oxysophocarpine 1-oxy-13,14-didehydro-matridin-15-one 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, 4-oxide, (7aS,13aR,13bR,13cS)- Matridin-15-one, 13,14-didehydro-, 1-oxide (4R,7aS,13aR,13bR,13cS)-2,3,6,7,7a,8,13,13a,13b,13c-Decahydro-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one 4-oxide 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, 4-oxide, (4R,7aS,13aR,13bR,13cS)-

Description	Oxysophocarpine is an alkaloid extracted from Siphocampylus verticillatus. Oxysophocarpine has neuroprotective and anti-nociceptive effects on the central and peripheral nervous systems[1]. Oxysophocarpine inhibits the growth and metastasis of oral squamous cell carcinoma (OSCC)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Oxysophocarpine (5 μM) inhibits proliferation and reduces migration and invasion of SCC-9 and SCC-15 oral squamous cell carcinoma (OSCC) cells in vitro[1].
References	[1]. Xu T, et al. Oxysophocarpine induces anti-nociception and increases the expression of GABAAα1 receptors in mice.Mol Med Rep. 2013 Jun;7(6):1819-25. [2]. Liu, R., Peng, J., Wang, H., et al. Oxysophocarpine retards the growth and metastasis of oral squamous cell carcinoma by targeting the Nrf2/HO-1 axis. Cell Physiol. Biochem. 49(5), 1717-1733 (2018).

Molecular Formula	C₁₅H₂₂N₂O₂
Molecular Weight	262.347
Exact Mass	262.168121
PSA	49.74000
LogP	-0.41

6483-15-4

~66%

26904-64-3

Literature: CSPC Zongqi Pharmaceutical Technology (Shijiahuang) Co., Ltd.; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences; Jiang, Jiandong; Song, Danqing; Du, Nana; Peng, Zonggen; Wang, Yuping; Gao, Limei; Han, Yanxing; Li, Xin; Li, Chunxin Patent: US2013/190345 A1, 2013 ; Location in patent: Paragraph 0619 ;

Precursor 1
6483-15-4
DownStream 1
519-02-8

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