6483-15-4

6483-15-4 structure

Name: Sophocarpine
Chemical Name: Sophocarpine
CAS Number: 6483-15-4
Molecular Formula: C₁₅H₂₂N₂O
Molecular Weight: 246.348
Catalog: Natural product Alkaloid
Create Date: 2018-04-21 08:00:00
Modify Date: 2024-01-03 11:40:36
Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer[1].

Name	Sophocarpine
Synonyms	1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, (7aS,13aR,13bR,13cS)- Sophocarpine Matridine-13-ene-15-one Matridin-15-one, 13,14-didehydro- Matridin-15-one, 13,14-didehydro- (9CI) 13,14-Didehydromatridin-15-one

Description	Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> PI3K Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> PI3K/Akt/mTOR >> Akt Research Areas >> Inflammation/Immunology
Target	PI3K Akt
References	[1]. Huang Y, et al. Sophocarpine inhibits the growth of gastric cancer cells via autophagy and apoptosis. Front Biosci (Landmark Ed). 2019 Mar 1;24:616-627.

519-02-8

6483-15-4

Literature: Tetrahedron Letters, , vol. 55, # 4 p. 950 - 953