944111-22-2

944111-22-2 structure

Name: PG 106 TFA
Chemical Name: L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-β-alanyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-, (2→7)-lactam
CAS Number: 944111-22-2
Molecular Formula: C₅₁H₆₉N₁₃O₉
Molecular Weight: 1008.18000
Catalog: Research Areas Inflammation/Immunology
Create Date: 2016-02-23 07:54:06
Modify Date: 2025-08-21 03:31:44
PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50=210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor[1].

Name	L-Lysinamide, N-acetyl-L-norleucyl-L-α-aspartyl-β-alanyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-, (2→7)-lactam
Synonyms	MMPIP hydrochloride

Description	PG106 is a potent and selective human melanocortin 3 (hMC3) receptor antagonist (IC50=210 nM) and has noactivity at hMC4 receptors (EC50=9900 nM) and hMC5 receptor[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Melanocortin Receptor
Target	IC50: 210 nM (hMC3 receptor) EC50: 9900 nM (hMC4 receptor)[1]
References	[1]. Paolo Grieco, et al. Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5. Peptides