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ShangHai DC Chemicals Co.,Ltd
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Dayang Chem (Hangzhou) Co., Ltd.
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768-94-5

768-94-5 structure

Name: Adamantan-1-amine
Chemical Name: amantadine
CAS Number: 768-94-5
Molecular Formula: C₁₀H₁₇N
Molecular Weight: 151.249
Catalog: API Nervous system medication Anti-shock palsy
Create Date: 2018-02-05 08:00:00
Modify Date: 2024-01-02 12:58:06
Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].

Name	amantadine
Synonyms	1-Adamantanamine EXP 105-1 1-Amantadine (3s,5s,7s)-adamantan-1-amine adamantan-1-amine tricyclo[3.3.1.13,7]decan-1-amine Symmetrel TCMDC-125869 Tricyclo[3.3.1.1]decan-1-amine SYMADINE 1-Adamantylamine Mydantane (3s,5s,7s)-1-Adamantanamine adamantylamine EINECS 212-201-2 Amantadine 1-Aminotricyclo[3.3.1.13,7]decane Adamantanamine 1-aminoadamantine adamantyl amine tricyclo[3.3.1.1]décan-1-amine Trivaline Pk-merz Amazolon 1-Aminodiamantane 1-adamantaneamine 1-aminoadamantane MFCD00074732 Aminoadamantane Mantadine Tricyclo[3.3.1.1^3,7]decan-1-amine Virofral 1-aminoadamantan Tricyclo[3.3.1.1]decan-1-amin Virasol Amantadine Base Influenol 1-Adamantanamine (8CI) Adamantamine

Description	Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].
Related Catalog	Signaling Pathways >> Anti-infection >> Influenza Virus Research Areas >> Infection
References	[1]. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200. [2]. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.

Density	1.1±0.1 g/cm3
Boiling Point	225.7±8.0 °C at 760 mmHg
Melting Point	206-208 °C(lit.)
Molecular Formula	C₁₀H₁₇N
Molecular Weight	151.249
Flash Point	96.0±9.7 °C
Exact Mass	151.136093
PSA	26.02000
LogP	2.22
Vapour Pressure	0.1±0.4 mmHg at 25°C
Index of Refraction	1.558

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YD1925000

CHEMICAL NAME :: Tricyclo(3.3.1.1(sup 3,7))decan-1-amine

CAS REGISTRY NUMBER :: 768-94-5

LAST UPDATED :: 199706

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C10-H17-N

MOLECULAR WEIGHT :: 151.28

WISWESSER LINE NOTATION :: L66 B6 A B- C 1B ITJ BZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 900 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 223 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 700 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 245 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: DNA adduct

TEST SYSTEM :: Bacteria - Escherichia coli

DOSE/DURATION :: 10 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 89,95,1981

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R22;R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YD1925000

Precursor 8
24886-73-5 7575-82-8 665-66-7 5689-59-8
56432-99-6 768-95-6 91233-19-1 3667-65-0
DownStream 10
37818-93-2 3717-60-0 57527-54-5 4411-25-0
5689-59-8 3717-38-2 4411-26-1 15004-38-3
22734-10-7 7575-82-8

768-94-5	33211-90-4
31377-23-8	78056-28-7
33187-62-1	3717-60-0
3667-90-1	251323-81-6
42194-25-2	915922-22-4
1158522-08-7	940364-43-2
2443964-95-0	134104-43-1
131615-57-1	2228587-49-1
2680672-48-2	6906-52-1
930439-75-1	1018584-77-4