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520-26-3

520-26-3 structure
520-26-3 structure
  • Name: Hesperidin
  • Chemical Name: hesperidin
  • CAS Number: 520-26-3
  • Molecular Formula: C28H34O15
  • Molecular Weight: 610.561
  • Catalog: API Circulatory system medication Regulating blood lipids
  • Create Date: 2018-02-08 08:00:00
  • Modify Date: 2025-08-20 10:43:15
  • Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols, since it possesses biological and pharmacological properties as an effective antioxidant, anti-inflammatory, anti-carcinogenic, and anti-hypertensive agent with lipid-lowering activity[1]IC50: hesperidin (IC50=116.68μmo/L))[4]in vitro: hesperidin and linarin are two of the main constituent of Valeriana's extract exhibiting a high affinity to KATP channel, which are related to the control of Ca++ concentration and release of GABA in synaptic nerve terminal, mainly on cells of SN[2]in vivo: Hesperidin was dissolved in 1% carboxymethyl cellulose (CMC) and administered orally at a dose of 50 mg/kg for 10 consecutive days. In the control group, rats were treated with the corn oil and 1% CMC vehicle.[1]
Name hesperidin
Synonyms usafcf-3
Hesperetin 7-rhamnoglucoside,Hesperitin-7-rutinoside
VITAMIN P
Hespeidin
Hespiridin
Hesperiden
Neobiletin
cirantin
MFCD00075663
Hesperetin7-rutinoside
Cirontin
Hesperidoside
Hesperetin7-rhamnoglucoside
Hesperidin
EINECS 208-288-1
Description Hesperidin (HP) is a bioflavonoid that plays a role in plant defense and is abundant in citrus species, such as grapefruit, lemon and orange. Hesperidin is used effectively as a supplemental agent in complementary therapy protocols, since it possesses biological and pharmacological properties as an effective antioxidant, anti-inflammatory, anti-carcinogenic, and anti-hypertensive agent with lipid-lowering activity[1]IC50: hesperidin (IC50=116.68μmo/L))[4]in vitro: hesperidin and linarin are two of the main constituent of Valeriana's extract exhibiting a high affinity to KATP channel, which are related to the control of Ca++ concentration and release of GABA in synaptic nerve terminal, mainly on cells of SN[2]in vivo: Hesperidin was dissolved in 1% carboxymethyl cellulose (CMC) and administered orally at a dose of 50 mg/kg for 10 consecutive days. In the control group, rats were treated with the corn oil and 1% CMC vehicle.[1]
Related Catalog
References

[1]. Asli Cetin, Ali Otlu et al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachloride administration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3): 486-493.

[2]. Gesivaldo Santos, Bruno Andrade et al. SUR1 Receptor Interaction with Hesperidin and Linarin Predicts Possible Mechanisms of Action of Valeriana officinalis in Parkinson. Front Aging Neurosci, 2016, 8: 97.

[3]. Jin Zhang, Jing Gao et al. Hesperidin inhibits HeLa cell proliferation through apoptosis mediated by endoplasmic reticulum stress pathways and cell cycle arrest. BMC Cancer, 2015, 15: 682.

[4]. Cetin A, Otlu A, ea al. Protective effect of hesperidin on oxidative and histological liver damage following carbon tetrachlorideadministration in Wistar rats. Arch Med Sci, 2016 Jun 1, 12(3):486-93.
Density 1.7±0.1 g/cm3
Boiling Point 930.1±65.0 °C at 760 mmHg
Melting Point 250-255 °C (dec.)(lit.)
Molecular Formula C28H34O15
Molecular Weight 610.561
Flash Point 305.5±27.8 °C
Exact Mass 610.189758
PSA 234.29000
LogP 1.78
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.695

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MK6650000
CHEMICAL NAME :
Hesperidin
CAS REGISTRY NUMBER :
520-26-3
BEILSTEIN REFERENCE NO. :
0075140
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C28-H34-O15
MOLECULAR WEIGHT :
610.62
WISWESSER LINE NOTATION :
T66 BO EVT&J CR CQ DO1& GQ IO- BT6OTJ CQ DQ EQ F1O- BT6OTJ CQ DQ EQ F1 GLUCO RHAMNO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84694 No. of Facilities: 156 (estimated) No. of Industries: 2 No. of Occupations: 10 No. of Employees: 8654 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R22
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS MK6650000
161713-86-6 structure

161713-86-6

~%

520-26-3 structure

520-26-3

Literature: Yamada, Mika; Tanabe, Fujimi; Arai, Norie; Mitsuzumi, Hitoshi; Miwa, Yoshikatsu; Kubota, Michio; Chaen, Hiroto; Kibata, Masayoshi Bioscience, Biotechnology and Biochemistry, 2006 , vol. 70, # 6 p. 1386 - 1394
161713-86-6 structure

161713-86-6

~%

520-26-3 structure

520-26-3

520-33-2 structure

520-33-2

Literature: Yamada, Mika; Tanabe, Fujimi; Arai, Norie; Mitsuzumi, Hitoshi; Miwa, Yoshikatsu; Kubota, Michio; Chaen, Hiroto; Kibata, Masayoshi Bioscience, Biotechnology and Biochemistry, 2006 , vol. 70, # 6 p. 1386 - 1394
64-17-5 structure

64-17-5

50376-44-8 structure

50376-44-8

~%

520-26-3 structure

520-26-3

Literature: Shimokoriyama Journal of the American Chemical Society, 1957 , vol. 79, p. 4199,4200
64726-90-5 structure

64726-90-5

~%

369593-42-0 structure

369593-42-0

520-26-3 structure

520-26-3

Literature: Belboukhari, Nasser; Cheriti, Abdelkrim; Roussel, Christian; Vanthuyne, Nicolas Natural Product Research, 2010 , vol. 24, # 7 p. 669 - 681
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