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  • Product Name: Timosaponin A3
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Related CAS#:
41059-79-4 149817-67-4
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41059-79-4

41059-79-4 structure
41059-79-4 structure
  • Name: Timosaponin A3
  • Chemical Name: Timosaponin A-III
  • CAS Number: 41059-79-4
  • Molecular Formula: C39H64O13
  • Molecular Weight: 740.918
  • Catalog: Biochemical Plant extracts
  • Create Date: 2018-09-28 17:39:23
  • Modify Date: 2024-01-04 10:58:40
  • Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM.
Name Timosaponin A-III
Synonyms Timosaponin A3
XilingsaponinA
(3β,5β)-Spirostan-3-yl 2-O-β-D-glucopyranosyl-β-D-galactopyranoside
Filiferin B
β-D-Galactopyranoside, (3β,5β)-spirostan-3-yl 2-O-β-D-glucopyranosyl-
Timosaponina-
Description Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM.
Related Catalog
Target

IC50: 35.4 μM (AChE)[1].
In Vitro Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM[1]. Timosaponin AIII is identified as a major selective cytotoxic activity in BN108, and its selective cytotoxic activity involves inhibition of mTOR, induction of ER stress and protective autophagy[2].
In Vivo Of the tested steroidal saponins, Timosaponin AIII (TA3) most potently improves memory deficits. Timosaponin AIII increases the scopolamine-induced reduction in step-through latency by 17% (10 mg/kg), 28% (20 mg/kg), and 43% (40 mg/kg). During the acquisition trial, no differences in latent time are observed. Timosaponin AIII (20, 40 mg/kg, p.o.) potently inhibits this reduction of acetylcholine in scopolamine-treated mouse brain. The inhibitory effect of Timosaponin AIII is comparable to that of tacrine, which is used as a positive control[1].
Animal Admin Mice[1] Male ICR mice weighing 28-30 g are used. For the acquisition trial, mice are initially placed in the illuminated compartment and the door between the two compartments is opened 10 s later. Each group contains ten mice. One hour or 5 h before the acquisition trial, mice receive each test agent (e.g., Timosaponin AIII 10, 20 or 40 mg/kg, p.o. ). One hour before the acquisition trial, mice receive tacrine (10 mg/kg, p.o.) as a positive control. Memory impairment is induced by scopolamine treatment (1 mg/kg, i.p.) 0.5 h or 4.5 h after the administration of test agents, tacrine, or 10% Tween 80 solution. Control animals are administered 10% Tween 80 solution alone. Twenty-four hours after the acquisition trial, the mice are again placed in the illuminated compartment for retention trials. The time taken for a mouse to enter the dark compartment after the door opened is measured as the latency time in both acquisition and retention trials, with a maximum of 300 s[1].
References

[1]. Lee B, et al. Timosaponin AIII, a saponin isolated from Anemarrhena asphodeloides, ameliorates learning and memory deficits in mice. Pharmacol Biochem Behav. 2009 Aug;93(2):121-7.

[2]. King FW, et al. Timosaponin AIII is preferentially cytotoxic to tumor cells through inhibition of mTOR and induction of ER stress. PLoS One. 2009 Sep 30;4(9):e7283.
Density 1.4±0.1 g/cm3
Boiling Point 862.8±65.0 °C at 760 mmHg
Molecular Formula C39H64O13
Molecular Weight 740.918
Flash Point 475.6±34.3 °C
Exact Mass 740.434692
PSA 196.99000
LogP 3.94
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.606
Hazard Codes Xn
107800-07-7 structure

107800-07-7

~%

41059-79-4 structure

41059-79-4
Literature: Kintya, P. K.; Shvets, S. A. Chemistry of Natural Compounds, 1984 , vol. 20, p. 575 - 578 Khimiya Prirodnykh Soedinenii, 1984 , # 5 p. 610 - 614
Precursor  1

DownStream  0


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