87893-54-7

87893-54-7 structure

Name: Delta-12-Prostaglandin J2
Chemical Name: 13,14-dihydro-Δ12-prostaglandin J2
CAS Number: 87893-54-7
Molecular Formula: C₂₀H₃₀O₄
Molecular Weight: 334.450
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2016-03-07 16:05:38
Modify Date: 2024-01-13 20:20:42
Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation[1][2].

Name	13,14-dihydro-Δ12-prostaglandin J2
Synonyms	12-PROSTAGLANDIN J2 (5Z,12E,15S)-15-Hydroxy-11-oxoprosta-5,9,12-trien-1-oic acid (5Z,12E,15S)-11-Oxo-15-hydroxyprosta-5,9,12-triene-1-oic acid DELTA12-PGJ2 Prosta-5,9,12-trien-1-oic acid, 15-hydroxy-11-oxo-, (5Z,12E,15S)- 11-OXO-15S-HYDROXY-PROSTA-5Z,9,12E-TRIEN-1-OIC ACID 13,14-dihydro-Delta(12)-prostaglandin J2 13,14-dihydro-δ(12)-prostaglandin J2 DELTA12-PROSTAGLANDIN J2 9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2

Description	Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
Target	Human Endogenous Metabolite
References	[1]. Kim BE, et al. Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by Delta12-prostaglandin J2. Exp Mol Med. 2004;36(5):444-453.