115338-32-4

115338-32-4 structure

Name: NAN-190 hydrobromide
Chemical Name: NAN 190 hydrobromide
CAS Number: 115338-32-4
Molecular Formula: C₂₃H₂₈BrN₃O₃
Molecular Weight: 474.39100
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-07-31 11:29:03
Modify Date: 2024-01-02 22:08:44
NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.Target: 5-HT in vitro: NAN-190 is a 5-HT1A antagonist. [3] NAN-190 is a selective antagonist of 5-HT1A. [1]in vivo: NAN-190 (0.5 mg/kg, ip), as a 5-HT1A receptor antagonist, is injected concomitantly with the effective dose of fluoxetine. NAN-190 (5-HT1A receptor antagonist) reverses the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats. [2]

Name	NAN 190 hydrobromide
Synonyms	1-(2-Methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine hydrobromide 1-[2-METHOXYPHENYL]-4-[4-(2-PHTHALIMIDO)-BUTYL]PIPERAZINE HYDROCHLORIDE NAN-190 HYDROCHLORIDE NAN-190 HYDROBROMIDE NAN-190 (hydrobromide)

Description	NAN-190 hydrobromide is a serotonin receptor 5-HT antagonist. NAN-190 is a selective antagonist of 5-HT1A.Target: 5-HT in vitro: NAN-190 is a 5-HT1A antagonist. [3] NAN-190 is a selective antagonist of 5-HT1A. [1]in vivo: NAN-190 (0.5 mg/kg, ip), as a 5-HT1A receptor antagonist, is injected concomitantly with the effective dose of fluoxetine. NAN-190 (5-HT1A receptor antagonist) reverses the catalepsy-improving effect of fluoxetine in 6-OHDA lesioned rats. [2]
Related Catalog	Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease
References	[1]. Shahane SA, et al. Detection of phospholipidosis induction: a cell-based assay in high-throughput and high-content format. J Biomol Screen. 2014 Jan;19(1):66-76. [2]. Sharifi H, et al. Dose-Dependent Effect of Flouxetine on 6-OHDA-Induced Catalepsy in Male Rats: A Possible Involvement of 5-HT1A Receptors. Adv Pharm Bull. 2013;3(1):203-6. [3]. Citó MC, et al. Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice: evidence for involvement of the monoaminergic system. Braz J Med Biol Res. 2015 Jan;48(1):57-64.

3598-60-5

5464-78-8

115338-32-4

136918-14-4

115338-32-4

Precursor 2
3598-60-5 5464-78-8
DownStream 0

HS Code	2933599090
Summary	2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%