2898-76-2

2898-76-2 structure

Name: Benzamil
Chemical Name: 3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide
CAS Number: 2898-76-2
Molecular Formula: C₁₃H₁₄ClN₇O
Molecular Weight: 356.21100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2019-01-01 17:05:58
Modify Date: 2024-01-02 14:20:25
Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3].

Name	3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide
Synonyms	GNF-Pf-192 Benzamil 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid benzylcarbamimidoyl-amide

Description	Benzamil (Benzylamiloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM[1][2][3].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel
In Vitro	Benzamil (Benzylamiloride) inhibits neuronal and heterologously expressed small conductance Ca2+-activated K2+ channels[4].
In Vivo	Benzamil (Benzylamiloride) (0.7 mg/kg/day; s.c.) treated stroke-prone spontaneously hypertensive rats (SHRSP) survived, on average, until 16.1 weeks of age in SHRSP rats[5].
References	[1]. Fischer KG, et al. Characterization of a Na(+)-Ca(2+) exchanger in podocytes. Nephrol Dial Transplant. 2002 Oct;17(10):1742-50. [2]. Wang X, et al. Effects of amiloride, benzamil, and alterations in extracellular Na+ on the rat afferent arteriole and its myogenic response. Am J Physiol Renal Physiol. 2008 Jul;295(1):F272-82. [3]. Dai XQ, et al. Inhibition of TRPP3 channel by amiloride and analogs. Mol Pharmacol. 2007 Dec;72(6):1576-85. [4]. Castañeda MS, et al. Benzamil inhibits neuronal and heterologously expressed small conductance Ca2+-activated K+channels. Neuropharmacology. 2019 Nov 1;158:107738. [5]. Teiwes J, et al. Epithelial sodium channel inhibition in cardiovascular disease. A potential role for amiloride. Am J Hypertens. 2007 Jan;20(1):109-17.

Molecular Formula	C₁₃H₁₄ClN₇O
Molecular Weight	356.21100
Exact Mass	355.07200
PSA	145.30000
LogP	3.59470
Storage condition	2-8°C

Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	UN 2811
HS Code	2934999090

1431937-44-8

100-46-9

~73%

2898-76-2

Literature: BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KLEY, Joerg; HAERLE, Daniel; LINZ, Guenter; STEHLE, Sandra Patent: WO2013/64451 A1, 2013 ; Location in patent: Page/Page column 37; 38 ;

4878-36-8

2898-76-2

Literature: BOEHRINGER INGELHEIM INTERNATIONAL GMBH; KLEY, Joerg; HAERLE, Daniel; LINZ, Guenter; STEHLE, Sandra Patent: WO2013/64451 A1, 2013 ;

Precursor 2
100-46-9 4878-36-8
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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