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  • DC Chemicals Limited
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  • Product Name: RG14620
  • Price: $300.0/100mg $600.0/250mg $1200.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao
Hot CAS#:
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136831-49-7

136831-49-7 structure
136831-49-7 structure
  • Name: RG14620
  • Chemical Name: tyrphostin rg 14620
  • CAS Number: 136831-49-7
  • Molecular Formula: C14H8Cl2N2
  • Molecular Weight: 275.133
  • Catalog: Research Areas Cancer
  • Create Date: 2016-03-03 12:43:44
  • Modify Date: 2024-01-03 12:05:07
  • RG14620 is an EGFR inhibitor with an IC50 of 3 μM.
Name tyrphostin rg 14620
Synonyms MFCD00236445
3-Pyridineacetonitrile, α-[(3,5-dichlorophenyl)methylene]-, (αZ)-
2-(3',5'-Dichlorophenyl)-1-(3''-pyridinyl)acrylonitrile
(2Z)-3-(3,5-Dichlorophenyl)-2-(3-pyridinyl)acrylonitrile
3-Pyridineacetonitrile, α-[(3,5-dichlorophenyl)methylene]-, (αE)-
(2E)-3-(3,5-Dichlorophenyl)-2-(3-pyridinyl)acrylonitrile
3-Pyridineacetonitrile, α-((3,5-dichlorophenyl)methylene)-
RG-14620
Description RG14620 is an EGFR inhibitor with an IC50 of 3 μM.
Related Catalog
Target

EGFR:3 μM (IC50, Cell Assay)

In Vitro RG14620 inhibits colony formation (IC50=3 μM) and DNA synthesis (IC50=1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC50=4 μM) and DNA synthesis (IC50=1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible[2].
In Vivo RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals[2].
Cell Assay MH-85 cells and HER 14 cells are plated in complete medium, either αMEM or DMEM, respectively, supplemented with 10% FCS. After overnight culture, the culture medium is switched to αMEM supplemented with 0.2% PCS and 50 ng/mL EGF (MH-85) or DMEM supplemented with 0.5% PCS and 50 ng/mL EGF (HER14). The cells are cultured in this medium in the presence or absence of increasing concentrations of RG-13022 or RG-14620 for 10 days. At the end of culture, the cells are fixed with 4% (v/v) formaldehyde in calcium-magnesium-free phosphate-buffered saline for 15 min at room temperature and stained with hematoxylin. Numbers of colonies including more than 20 cells in each well are counted under the microscope[2].
Animal Admin Mice: RG14620 in 0.1 mL 100% DMSO is injected i.p. twice a day from 1day after MH-85 tumor inoculation. Control animals are given the same vehicle[1].
References

[1]. Sagara Y, et al. Tyrphostins protect neuronal cells from oxidative stress. J Biol Chem. 2002 Sep 27;277(39):36204-15.

[2]. Yoneda T, et al. The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice. Cancer Res. 1991 Aug 15;51(16):4430-5.
Density 1.4±0.1 g/cm3
Boiling Point 418.2±45.0 °C at 760 mmHg
Melting Point 155 °C
Molecular Formula C14H8Cl2N2
Molecular Weight 275.133
Flash Point 206.7±28.7 °C
Exact Mass 274.006439
PSA 36.68000
LogP 4.47
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.657
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport

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title: CAS No. 136831-49-7 | Chemsrc address: https://m.chemsrc.com/en/baike/402826.html

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