346-18-9

346-18-9 structure

Name: polythiazide (200 mg)
Chemical Name: 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
CAS Number: 346-18-9
Molecular Formula: C₁₁H₁₃ClF₃N₃O₄S₃
Molecular Weight: 439.88200
Catalog: API Urinary system medication Diuretic
Create Date: 2018-06-07 20:34:32
Modify Date: 2024-01-14 13:48:41
Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity[1][2][3].

Name	6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide
Synonyms	Polythiazide Polythiazidum Politiazida Nephril P-2525 Renese Drenusil

Description	Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
In Vitro	Polythiazide (500 μM, 1 min) induces significant phototoxic NHIK 3025 cell death under Bluelight 2000 apparatus (Ex: 325 nM)[2].
In Vivo	Polythiazide (oral gavage, 10 mg/kg, daily for 5 days) Increased plasma cholesterol levels in Cholesterol-fed C57BL/cdJ mouse[3]. Polythiazide (Oral administration, 0.4 mg/k g) shows diuretic and saluretic effects in hypertensive dogs and rats[1]. Animal Model: Cholesterol-fed C57BL/cdJ mice[3] Dosage: 10 mg/kg Administration: Oral gavage, daily for 5 days Result: Caused approximately 13% rise in total plasma cholesterol levels, and increased non-HDL lipoprotein fraction. Animal Model: Hypertensive dogs[1] Dosage: 0.4 mg/kg Administration: Oral administration, daily for 5 days Result: Increased in excretion of sodium and chloride. Animal Model: Hypertensive rats[1] Dosage: 0.05, 0.1, 0.2, 0.4 mg/k g Administration: Oral administration, twice a day for 3 days. Result: Displayed natriuretic and chloruretic effects.
References	[1]. A SCRIABINE, et al. Pharmacological studies with polythiazide, a new diuretic and antihypertensive agent. Proc Soc Exp Biol Med. 1961 Aug-Sep;107:864-72. [2]. E Selvaag, et al. Phototoxicity due to sulphonamide derived oral antidiabetics and diuretics: investigations in a cell culture model. Photodermatol Photoimmunol Photomed. 1996 Feb;12(1):1-6. [3]. M N Krupp, et al. Effects of doxazosin and other antihypertensives on serum lipid levels and lipoprotein lipase in the C57BR/cdJ mouse. J Cardiovasc Pharmacol. 1989;13 Suppl 2:S11-8; discussion S18-9.

Density	1.598g/cm3
Boiling Point	580.1ºC at 760mmHg
Melting Point	202.5°
Molecular Formula	C₁₁H₁₃ClF₃N₃O₄S₃
Molecular Weight	439.88200
Flash Point	304.7ºC
Exact Mass	438.97100
PSA	151.63000
LogP	4.59280
Index of Refraction	1.566

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DK9275000

CHEMICAL NAME :: 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl- 3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-dioxide

CAS REGISTRY NUMBER :: 346-18-9

LAST UPDATED :: 199709

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C11-H13-Cl-F3-N3-O4-S3

MOLECULAR WEIGHT :: 439.90

WISWESSER LINE NOTATION :: T66 BSWN EM DHJ C1 D1S1XFFF HG ISZW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 300 ug/kg/5D-I

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - coma Nutritional and Gross Metabolic - other changes

REFERENCE :: AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946- Volume(issue)/page/year: 70,1163,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,793,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959- Volume(issue)/page/year: 21,775,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 29ZVAB "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969 Volume(issue)/page/year: -,97,1969

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