polythiazide (200 mg)
Modify Date: 2026-09-29 21:14:23
polythiazide (200 mg) structure
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Common Name | polythiazide (200 mg) | ||
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| CAS Number | 346-18-9 | Molecular Weight | 439.88200 | |
| Density | 1.598g/cm3 | Boiling Point | 580.1ºC at 760mmHg | |
| Molecular Formula | C11H13ClF3N3O4S3 | Melting Point | 202.5° | |
| MSDS | N/A | Flash Point | 304.7ºC | |
Use of polythiazide (200 mg)Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity[1][2][3]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity[1][2][3]. |
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| Related Catalog | |
| In Vitro | Polythiazide (500 μM, 1 min) induces significant phototoxic NHIK 3025 cell death under Bluelight 2000 apparatus (Ex: 325 nM)[2]. |
| In Vivo | Polythiazide (oral gavage, 10 mg/kg, daily for 5 days) Increased plasma cholesterol levels in Cholesterol-fed C57BL/cdJ mouse[3]. Polythiazide (Oral administration, 0.4 mg/k g) shows diuretic and saluretic effects in hypertensive dogs and rats[1]. Animal Model: Cholesterol-fed C57BL/cdJ mice[3] Dosage: 10 mg/kg Administration: Oral gavage, daily for 5 days Result: Caused approximately 13% rise in total plasma cholesterol levels, and increased non-HDL lipoprotein fraction. Animal Model: Hypertensive dogs[1] Dosage: 0.4 mg/kg Administration: Oral administration, daily for 5 days Result: Increased in excretion of sodium and chloride. Animal Model: Hypertensive rats[1] Dosage: 0.05, 0.1, 0.2, 0.4 mg/k g Administration: Oral administration, twice a day for 3 days. Result: Displayed natriuretic and chloruretic effects. |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Density | 1.598g/cm3 |
|---|---|
| Boiling Point | 580.1ºC at 760mmHg |
| Melting Point | 202.5° |
| Molecular Formula | C11H13ClF3N3O4S3 |
| Molecular Weight | 439.88200 |
| Flash Point | 304.7ºC |
| Exact Mass | 438.97100 |
| PSA | 151.63000 |
| LogP | 4.59280 |
| Index of Refraction | 1.566 |
| InChIKey | CYLWJCABXYDINA-UHFFFAOYSA-N |
| SMILES | CN1C(CSCC(F)(F)F)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Polythiazide |
| Polythiazidum |
| Politiazida |
| Nephril |
| P-2525 |
| Renese |
| Drenusil |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What English synonyms does 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide have? |
| A: English synonyms of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide: Polythiazide, Polythiazidum, Politiazida, Nephril, P-2525, Renese, Drenusil. |
| Q: What is the English name of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide? |
| A: The English name of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide. |
| Q: What is the polar surface area (PSA) of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide? |
| A: Polar surface area (PSA) of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is 151.63000. |
| Q: What is the molecular formula of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide? |
| A: Molecular formula of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is C11H13ClF3N3O4S3. |
| Q: What is the molecular weight of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide? |
| A: Molecular weight of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is 439.88200. |
| Q: What is the LogP of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide? |
| A: LogP of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is 4.59280. |
| Q: What is the InChIKey of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide? |
| A: InChIKey of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is CYLWJCABXYDINA-UHFFFAOYSA-N. |
| Q: What is the SMILES notation of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide? |
| A: SMILES notation of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is CN1C(CSCC(F)(F)F)Nc2cc(Cl)c(S(N)(=O)=O)cc2S1(=O)=O. |
| Q: What are the uses of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide? |
| A: Main uses of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide: Polythiazide is a potent and orally active thiazide diuretic agent that has antihypertensive effect. Polythiazide can decrease edema and decrease blood pressure. Polythiazide also has phototoxicity[1][2][3]. |
| Q: What is the CAS number of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide? |
| A: CAS number of 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydro-1λ6,2,4-benzothiadiazine-7-sulfonamide is 346-18-9. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |