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19504-77-9

19504-77-9 structure
19504-77-9 structure
  • Name: 2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]-
  • Chemical Name: 1-[(2E,4E,6E,8R)-8-hydroxy-6-methyldodeca-2,4,6-trienoyl]pyrrolidin-2-one
  • CAS Number: 19504-77-9
  • Molecular Formula: C17H25NO3
  • Molecular Weight: 291.39
  • Catalog: Signaling Pathways Anti-infection Fungal
  • Create Date: 2018-09-28 14:23:25
  • Modify Date: 2024-02-07 12:21:07
  • Variotin is an Anti-Fungal Agent. Variotin has a strong antibiotic activity on dermatophytes such as Trichophyton, Microsporum, and Epidermophyton, and also pathogenic fungi in internal mycosis such as Blastomyces and Cryptococcus[1].

Name 1-[(2E,4E,6E,8R)-8-hydroxy-6-methyldodeca-2,4,6-trienoyl]pyrrolidin-2-one
Synonyms Leofungine
Supral
EINECS 243-116-9
Pecilocin
variotin
Description Variotin is an Anti-Fungal Agent. Variotin has a strong antibiotic activity on dermatophytes such as Trichophyton, Microsporum, and Epidermophyton, and also pathogenic fungi in internal mycosis such as Blastomyces and Cryptococcus[1].
Related Catalog
References

[1]. MATSUDA A, et al. Studies on antifungal activity of variotin. J Antibiot (Tokyo). 1959 Sep;12:203-9.  

Density 1.088g/cm3
Boiling Point 481.2ºC at 760mmHg
Molecular Formula C17H25NO3
Molecular Weight 291.39
Flash Point 244.8ºC
Exact Mass 291.18300
PSA 57.61000
LogP 2.68310
Vapour Pressure 2.79E-11mmHg at 25°C
Index of Refraction 1.538

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UY5777000
CHEMICAL NAME :
2-Pyrrolidinone, 1-(8-hydroxy-6-methyl-2,4,6-dodecatrienoyl)-, (E,E,E)-(R)-
CAS REGISTRY NUMBER :
19504-77-9
LAST UPDATED :
198104
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H25-N-O3
MOLECULAR WEIGHT :
291.43
WISWESSER LINE NOTATION :
T5NVTJ AV1U2U1Y1&U1YQ4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,2004,1978