2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]

Modify Date: 2025-09-10 20:56:42

2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl] structure	Common Name	2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]
	CAS Number	19504-77-9	Molecular Weight	291.39
	Density	1.088g/cm3	Boiling Point	481.2ºC at 760mmHg
	Molecular Formula	C₁₇H₂₅NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	244.8ºC

Use of 2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]

Variotin is an Anti-Fungal Agent. Variotin has a strong antibiotic activity on dermatophytes such as Trichophyton, Microsporum, and Epidermophyton, and also pathogenic fungi in internal mycosis such as Blastomyces and Cryptococcus[1].

Name	1-[(2E,4E,6E,8R)-8-hydroxy-6-methyldodeca-2,4,6-trienoyl]pyrrolidin-2-one
Synonym	More Synonyms

Description	Variotin is an Anti-Fungal Agent. Variotin has a strong antibiotic activity on dermatophytes such as Trichophyton, Microsporum, and Epidermophyton, and also pathogenic fungi in internal mycosis such as Blastomyces and Cryptococcus[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
References	[1]. MATSUDA A, et al. Studies on antifungal activity of variotin. J Antibiot (Tokyo). 1959 Sep;12:203-9.

Density	1.088g/cm3
Boiling Point	481.2ºC at 760mmHg
Molecular Formula	C₁₇H₂₅NO₃
Molecular Weight	291.39
Flash Point	244.8ºC
Exact Mass	291.18300
PSA	57.61000
LogP	2.68310
Vapour Pressure	2.79E-11mmHg at 25°C
Index of Refraction	1.538
InChIKey	ZYPGADGCNXOUJP-CXVPHVKISA-N
SMILES	CCCCC(O)C=C(C)C=CC=CC(=O)N1CCCC1=O

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY5777000

CHEMICAL NAME :: 2-Pyrrolidinone, 1-(8-hydroxy-6-methyl-2,4,6-dodecatrienoyl)-, (E,E,E)-(R)-

CAS REGISTRY NUMBER :: 19504-77-9

LAST UPDATED :: 198104

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H25-N-O3

MOLECULAR WEIGHT :: 291.43

WISWESSER LINE NOTATION :: T5NVTJ AV1U2U1Y1&U1YQ4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,2004,1978

Name: Inhibition of mouse DNA polymerase lambda assessed as inhibition of incorporation of ...
Source: ChEMBL
Target: DNA polymerase lambda
External Id: CHEMBL3132086

Name: Inhibition of bovine deoxyribonuclease 1 assessed as inhibition of incorporation of d...
Source: ChEMBL
Target: Deoxyribonuclease-1
External Id: CHEMBL3132087

Name: Inhibition of T4 bacteriophage polynucleotide kinase assessed as inhibition of incorp...
Source: ChEMBL
Target: Polynucleotide kinase
External Id: CHEMBL3132088

Name: USP8 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 8
External Id: USP8 FAST DUB HTS Primary

Name: Inhibition of mouse IMP dehydrogenase 2 assessed as inhibition of incorporation of dT...
Source: ChEMBL
Target: Inosine-5'-monophosphate dehydrogenase 2
External Id: CHEMBL3132089

Name: Inhibition of T7 RNA polymerase assessed as inhibition of incorporation of dTTP into ...
Source: ChEMBL
Target: T7 RNA polymerase
External Id: CHEMBL3132090

Name: USP17 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 17 like family member 5
External Id: USP17 FAST DUB HTS Primary

Name: Inhibition of calf DNA primase of polymerase alpha assessed as inhibition of incorpor...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3132091

Name: USP7 deubiquitinase inhibition: Primary qHTS
Source: 24642
Target: ubiquitin specific peptidase 7
External Id: USP7 FAST DUB HTS Primary

Name: Inhibition of HIV-1 reverse transcriptase assessed as inhibition of incorporation of ...
Source: ChEMBL
Target: Reverse transcriptase/RNaseH
External Id: CHEMBL3132092

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Leofungine

Supral

EINECS 243-116-9

Pecilocin

variotin

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2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]

Use of 2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Bioassay

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.