2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]-

Modify Date: 2024-02-07 12:21:07

2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]- structure	Common Name	2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]-
	CAS Number	19504-77-9	Molecular Weight	291.39
	Density	1.088g/cm3	Boiling Point	481.2ºC at 760mmHg
	Molecular Formula	C₁₇H₂₅NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	244.8ºC

Use of 2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]-

Variotin is an Anti-Fungal Agent. Variotin has a strong antibiotic activity on dermatophytes such as Trichophyton, Microsporum, and Epidermophyton, and also pathogenic fungi in internal mycosis such as Blastomyces and Cryptococcus[1].

Name	1-[(2E,4E,6E,8R)-8-hydroxy-6-methyldodeca-2,4,6-trienoyl]pyrrolidin-2-one
Synonym	More Synonyms

Description	Variotin is an Anti-Fungal Agent. Variotin has a strong antibiotic activity on dermatophytes such as Trichophyton, Microsporum, and Epidermophyton, and also pathogenic fungi in internal mycosis such as Blastomyces and Cryptococcus[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
References	[1]. MATSUDA A, et al. Studies on antifungal activity of variotin. J Antibiot (Tokyo). 1959 Sep;12:203-9.

Density	1.088g/cm3
Boiling Point	481.2ºC at 760mmHg
Molecular Formula	C₁₇H₂₅NO₃
Molecular Weight	291.39
Flash Point	244.8ºC
Exact Mass	291.18300
PSA	57.61000
LogP	2.68310
Vapour Pressure	2.79E-11mmHg at 25°C
Index of Refraction	1.538

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY5777000

CHEMICAL NAME :: 2-Pyrrolidinone, 1-(8-hydroxy-6-methyl-2,4,6-dodecatrienoyl)-, (E,E,E)-(R)-

CAS REGISTRY NUMBER :: 19504-77-9

LAST UPDATED :: 198104

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H25-N-O3

MOLECULAR WEIGHT :: 291.43

WISWESSER LINE NOTATION :: T5NVTJ AV1U2U1Y1&U1YQ4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85ERAY "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978 Volume(issue)/page/year: 3,2004,1978

Leofungine

Supral

EINECS 243-116-9

Pecilocin

variotin

2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]-

Use of 2-Pyrrolidinone,1-[(2E,4E,6E,8R)-8-hydroxy-6-methyl-1-oxo-2,4,6-dodecatrien-1-yl]-

Names

Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Synonyms