CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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DI3500000
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CHEMICAL NAME :
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Benzonitrile, 2,6-dichloro-
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CAS REGISTRY NUMBER :
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1194-65-6
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BEILSTEIN REFERENCE NO. :
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1909167
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LAST UPDATED :
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199801
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DATA ITEMS CITED :
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17
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MOLECULAR FORMULA :
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C7-H3-Cl2-N
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MOLECULAR WEIGHT :
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172.01
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WISWESSER LINE NOTATION :
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NCR BG FG
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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2710 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962- Volume(issue)/page/year: 10,97,1965
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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500 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,145,1971
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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2056 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969 Volume(issue)/page/year: 5,73,1976
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TYPE OF TEST :
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LD - Lethal dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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>200 mg/kg
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - deviated nasal septum Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Biochemical - Metabolism (Intermediary) - lipids including transport
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REFERENCE :
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NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 15,287,1994
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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360 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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FRPSAX Farmaco, Edizione Scientifica. (Casella Postale 227, 27100 Pavia, Italy) V.8-43 1953-88 For publisher information, see FRMCE8 Volume(issue)/page/year: 41,41,1986
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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270 mg/kg
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TOXIC EFFECTS :
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Behavioral - somnolence (general depressed activity) Liver - other changes
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REFERENCE :
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FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 6,261,1968
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - rabbit
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DOSE/DURATION :
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1350 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada) Volume(issue)/page/year: 6,177,1973
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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681 mg/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS) Volume(issue)/page/year: -,337,1966
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TYPE OF TEST :
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LD50 - Lethal dose, 50 percent kill
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ROUTE OF EXPOSURE :
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Unreported
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SPECIES OBSERVED :
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Mammal - species unspecified
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DOSE/DURATION :
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1 gm/kg
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TOXIC EFFECTS :
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Details of toxic effects not reported other than lethal dose value
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REFERENCE :
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30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971 Volume(issue)/page/year: -,144,1971 ** OTHER MULTIPLE DOSE TOXICITY DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Administration onto the skin
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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1 gm/kg/5D-I
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TOXIC EFFECTS :
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Sense Organs and Special Senses (Olfaction) - deviated nasal septum Sense Organs and Special Senses (Olfaction) - effect, not otherwise specified Biochemical - Metabolism (Intermediary) - lipids including transport
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REFERENCE :
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NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979- Volume(issue)/page/year: 15,287,1994 ** TUMORIGENIC DATA **
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Intraperitoneal
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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260 ug/kg/39D-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Tumorigenic - tumors at site of application
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REFERENCE :
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AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870- Volume(issue)/page/year: 122,107,1979
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Subcutaneous
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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260 ug/kg/39D-I
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TOXIC EFFECTS :
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Tumorigenic - equivocal tumorigenic agent by RTECS criteria Liver - tumors Tumorigenic - tumors at site of application
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REFERENCE :
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AAATAP Annali dell'Accademia di Agricoltura di Torino. (Accademia de Agricoltura di Torino, Via Andrea Doria 10, 10123 Turin, Italy) 1870- Volume(issue)/page/year: 122,107,1979 *** REVIEWS *** TOXICOLOGY REVIEW DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970. Volume(issue)/page/year: 80,485,1973 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 24030 No. of Facilities: 40 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 200 (estimated)
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