Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tibezonium iodide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

54663-47-7

54663-47-7 structure

54663-47-7 structure

Name: Tibezonium iodide
Chemical Name: Diethylmethyl[2-[[4-[p-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethyl]ammonium iodide
CAS Number: 54663-47-7
Molecular Formula: C₂₈H₃₂IN₃S₂
Molecular Weight: 601.60800
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-08-01 09:50:24
Modify Date: 2024-01-09 18:37:37
Tibezonium iodide, an oropharyngeal disinfectant, has antibacterial activity for the prevention of mouth infections[1].

Name	Diethylmethyl[2-[[4-[p-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethyl]ammonium iodide
Synonyms	tibezonium iodide tibenzonium iodide Antoral Ethanaminium,N,N-diethyl-N-methyl-2-[[4-[4-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]-,iodide Tibezonium N,N-Diethyl-N-methyl-2-[[4-[4-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethanaminium iodide Rec 15-0691 Thiabenzazonium 2-(Methyl-diaethylammonium-aethylthio)-4-(p-phenyl-thio-phenyl)-3H-1,5-benzodiazepin-jodid Tibezonium-jodid

Description	Tibezonium iodide, an oropharyngeal disinfectant, has antibacterial activity for the prevention of mouth infections[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Tibezonium iodide (5-10 μg/mL; 15-30 min) displays good bacteriostatic and bactericidal activity against gram-positive strain, especially against S. aureus and S. pyogens humanus with the minimum inhibitory concerntration (MIC) values ≤1 μg/mL)[3]. Tibezonium iodide (0.25-5 μg/mL; 30 min) displays increasing bactericidal activity against S. aureus and S. pyogens 821 while pH value going up from 6.5-7.0 to 8.0-8.5[3].
References	[1]. M Veronese, et al. Mutagenicity studies on tibezonium, a new oropharyngeal disinfectant. Arzneimittelforschung. 1983;33(3):369-72. [2]. M Calzavara, et al. [Clinico-experimental study of a new antibactorial agent for local use in stomatology]. Minerva Stomatol. Apr-Jun 1976;25(2):55-66. [3]. Veronese M, et al. Antimicrobial activity of tibezonium (TBZ). Chemotherapy. 1977. 23(2):90-7.

Melting Point	162ºC
Molecular Formula	C₂₈H₃₂IN₃S₂
Molecular Weight	601.60800
Exact Mass	601.10800
PSA	75.32000
LogP	3.48710

CHEMICAL IDENTIFICATION

RTECS NUMBER :: KH2770000

CHEMICAL NAME :: Ethanaminium, N,N-diethyl-N-methyl-2-((4-(4-(phenylthio)phenyl)- 3H-1,5-benzodiazepin-2-yl) thio)-, iodide

CAS REGISTRY NUMBER :: 54663-47-7

LAST UPDATED :: 199206

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C28-H32-N3-S2.I

MOLECULAR WEIGHT :: 601.65

WISWESSER LINE NOTATION :: T67 GN KN IHJ HS2K2&2&2 JR DSR &I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >10 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,152,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 9 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 42 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975