Tibezonium iodide

Modify Date: 2024-01-09 18:37:37

Tibezonium iodide Structure
Tibezonium iodide structure
 Common Name Tibezonium iodide
CAS Number 54663-47-7 Molecular Weight 601.60800
Density N/A Boiling Point N/A
Molecular Formula C28H32IN3S2 Melting Point 162ºC
MSDS N/A Flash Point N/A

 Use of Tibezonium iodide


Tibezonium iodide, an oropharyngeal disinfectant, has antibacterial activity for the prevention of mouth infections[1].

 Names

Name Diethylmethyl[2-[[4-[p-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethyl]ammonium iodide
Synonym More Synonyms

 Tibezonium iodide Biological Activity

Description Tibezonium iodide, an oropharyngeal disinfectant, has antibacterial activity for the prevention of mouth infections[1].
Related Catalog
In Vitro Tibezonium iodide (5-10 μg/mL; 15-30 min) displays good bacteriostatic and bactericidal activity against gram-positive strain, especially against S. aureus and S. pyogens humanus with the minimum inhibitory concerntration (MIC) values ≤1 μg/mL)[3]. Tibezonium iodide (0.25-5 μg/mL; 30 min) displays increasing bactericidal activity against S. aureus and S. pyogens 821 while pH value going up from 6.5-7.0 to 8.0-8.5[3].
References

[1]. M Veronese, et al. Mutagenicity studies on tibezonium, a new oropharyngeal disinfectant. Arzneimittelforschung. 1983;33(3):369-72.

[2]. M Calzavara, et al. [Clinico-experimental study of a new antibactorial agent for local use in stomatology]. Minerva Stomatol. Apr-Jun 1976;25(2):55-66.

[3]. Veronese M, et al. Antimicrobial activity of tibezonium (TBZ). Chemotherapy. 1977. 23(2):90-7.

 Chemical & Physical Properties

Melting Point 162ºC
Molecular Formula C28H32IN3S2
Molecular Weight 601.60800
Exact Mass 601.10800
PSA 75.32000
LogP 3.48710

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
KH2770000
CHEMICAL NAME :
Ethanaminium, N,N-diethyl-N-methyl-2-((4-(4-(phenylthio)phenyl)- 3H-1,5-benzodiazepin-2-yl) thio)-, iodide
CAS REGISTRY NUMBER :
54663-47-7
LAST UPDATED :
199206
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C28-H32-N3-S2.I
MOLECULAR WEIGHT :
601.65
WISWESSER LINE NOTATION :
T67 GN KN IHJ HS2K2&2&2 JR DSR &I

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 3,152,1978
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945- Volume(issue)/page/year: 31,440,1975

 Synonyms

tibezonium iodide
tibenzonium iodide
Antoral
Ethanaminium,N,N-diethyl-N-methyl-2-[[4-[4-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]-,iodide
Tibezonium
N,N-Diethyl-N-methyl-2-[[4-[4-(phenylthio)phenyl]-3H-1,5-benzodiazepin-2-yl]thio]ethanaminium iodide
Rec 15-0691
Thiabenzazonium
2-(Methyl-diaethylammonium-aethylthio)-4-(p-phenyl-thio-phenyl)-3H-1,5-benzodiazepin-jodid
Tibezonium-jodid
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Tibezonium iodide suppliers

Tibezonium iodide price

Related Compounds: More...
Tibezonium iodide
54663-44-4
Magnoflorine Iodide
4277-43-4
tetraethylarsanium,iodide
2185-81-1
hafnium iodide
13777-23-6
pentylmagnesium iodide
3814-99-1
Pentaiodide
88385-95-9
dibenziodolium, iodide
1010-76-0
Perfluorododecyl iodide
307-60-8
Sodium iodide
7681-82-5
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1158522-08-7
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
940364-43-2
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
134104-43-1
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
131615-57-1
(4-Methyl-tetrahydro-furan-2-yl)-methanol
6906-52-1
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
930439-75-1
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
1018584-77-4
tert-Butyl-DL-alanine
1375289-11-4
2-(1-Amino-3-methylbutyl)-6-bromo-4-chlorophenol
2090680-61-6
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
849349-65-1
Chemsrc provides Tibezonium iodide(CAS#:54663-47-7) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Tibezonium iodide are included as well.>> amp version: Tibezonium iodide

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved