Dayang Chem (Hangzhou) Co., Ltd.
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Product Name: 1H,12H-Benzo[i]pyrano[3,4-g]indolizin-12-one,2,3,5,6,8,9,10,13-octahydro-2-methoxy-, (2S,13bS)-
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23255-54-1

23255-54-1 structure

Name: 1H,12H-Benzo[i]pyrano[3,4-g]indolizin-12-one,2,3,5,6,8,9,10,13-octahydro-2-methoxy-, (2S,13bS)-
Chemical Name: dihydro-β-erythroidine
CAS Number: 23255-54-1
Molecular Formula: C₁₆H₂₁NO₃
Molecular Weight: 275.34300
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2016-10-24 10:27:56
Modify Date: 2024-01-16 23:53:21
Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced[1][2].

Name	dihydro-β-erythroidine
Synonyms	dihydro-beta-erythroidine 1-(2,6,6-trimethyl-1-cyclohexen-1-yl)butan-1-one .β.-Erythroidine, dihydro- 1-(2,6,6-trimethylcyclohex-1-en-1-yl)butan-1-one (12S,13aS)-)-12-methoxy-1,4,5,6,9,11,12,13-octahydro-8H-pyrano[4',3':3,4]pyrido[2,1-i]indol-2-one 1-Butyryl-2,6,6-trimethyl-cyclohexen (12S,13aS)-)-12-Methoxy-1,4,5,6,9,11,12,13-octahydro-8H-pyrano[4',3':3,4]pyrido[2,1-i]indol-2-on

Description	Dihydro-β-erythroidine is a a competitive nicotinic receptor antagonist. Dihydro-β-erythroidine blocks the discriminative stimulus properties of nicotine. Dihydro-β-erythroidine inhibits the anxiolytic effect of nicotine induced[1][2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vivo	Dihydro-β-erythroidine (0.5, 1.6, 5.0 mg/kg; s.c.) blocks the discriminative stimulus properties of nicotine in rats[1]. Dihydro-β-erythroidine (100 ng) shows antagonism of the anxiolytic effect of nicotine in the dorsal raphe´ nucleus in rats[2]. Animal Model: 200-250 g male hooded Lister rats[1] Dosage: 0.5, 1.6, 5.0 mg/kg Administration: S.c. Result: Prevented the development of CTAs (conditioned taste aversion) and blocked the discriminative stimulus effect of nicotine (0.2 or 0.4 mg/kg SC) for 45 min after its administration.
References	[1]. Shoaib M, et al. Antagonism of stimulus properties of nicotine by dihydro-beta-erythroidine (DHbetaE) in rats. Psychopharmacology (Berl). 2000 Apr;149(2):140-6. [2]. Cheeta S, et al. Antagonism of the anxiolytic effect of nicotine in the dorsal raphe nucleus by dihydro-beta-erythroidine. Pharmacol Biochem Behav. 2001 Dec;70(4):491-6.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 113,212,1955

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: RISSAF Rendiconti Istituto Superiore di Sanita (Italian Edition). (Rome, Italy) V.4-27, 1941-64. Volume(issue)/page/year: 12,158,1949