105265-96-1

105265-96-1 structure

Name: 2-Acetamido-1,2-dideoxynojirimycin
Chemical Name: 2-acetamido-1,2,5-trideoxy-1,5-imino-d-g lucitol
CAS Number: 105265-96-1
Molecular Formula: C₈H₁₆N₂O₄
Molecular Weight: 204.22400
Create Date: 2018-06-11 19:06:06
Modify Date: 2024-01-08 16:38:56
AB05831, also known as 2-Acetamido-1,2-dideoxynojirimycin, is a highly potent and specific inhibitor of beta-hexosaminidase. N-Acetyl-3-hexosaminidase (HEX) is a member of lysosomal hydrolases, which catalyzes hydrolysis of terminal, non-reducing N-acetyl-|3-D-glucosamine (GlcNAc) andN-acetyl-(3-D-galactosamine (GalNAc) residues in glycoproteins, gan-gliosides, and glycosaminoglycans (GAGs). HEX, released by chondrocytes into the extracellular compartment, promotes cartilage matrix degradation. Osteoarthritis patients have increased HEX activity in synovial fluid.

Name	2-acetamido-1,2,5-trideoxy-1,5-imino-d-g lucitol
Synonyms	5-acetamido-1,3,4-thiadiazole 2-acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol Acetamide,N-1,3,4-thiadiazol-2-yl 2-acetamido-1,2,5-trideoxy-1,5-imino-D-glucitol 2-acetylamino-1,3,4-thiadiazole 1,3,4-Thiadiazole,2-acetamido X 134 1,2-dideoxy-2-acetamidonojirimycin N-Acetyl-2-amino-1,3,4-thiadiazol 2-acetamido-1,2-dideoxynojirimycin

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport