87828-86-2

87828-86-2 structure

87828-86-2 structure

Name: L-Leucine-d3
Chemical Name: (2S)-2-amino-5,5,5-trideuterio-4-methylpentanoic acid
CAS Number: 87828-86-2
Molecular Formula: C₆H₁₀D₃NO₂
Molecular Weight: 134.191
Catalog: Signaling Pathways PI3K/Akt/mTOR mTOR
Create Date: 2018-06-19 15:37:06
Modify Date: 2024-01-03 10:19:52
L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].

Name	(2S)-2-amino-5,5,5-trideuterio-4-methylpentanoic acid
Synonyms	(S)-Leucine-d3 L-Leucine-5,5,5-d3 L-Leucine-5,5,5-d L-(5,5,5-H)Leucine MFCD00144628 L-\|A-Aminoisocaproic Acid-d3 L-Leucine-d3 (S)-2-Amino-4-methylvaleric Acid-d3 L-2-Amino-4-methylpentanoic Acid-d3

Description	L-Leucine-d3 is the deuterium labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
Related Catalog	Signaling Pathways >> PI3K/Akt/mTOR >> mTOR Research Areas >> Metabolic Disease
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

Density	1.0±0.1 g/cm3
Boiling Point	225.8±23.0 °C at 760 mmHg
Melting Point	>300ºC(lit.)
Molecular Formula	C₆H₁₀D₃NO₂
Molecular Weight	134.191
Flash Point	90.3±22.6 °C
Exact Mass	134.113464
PSA	63.32000
LogP	0.73
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.463
Storage condition	2-8°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport