100823-03-8

100823-03-8 structure

Name: TC11
Chemical Name: 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione
CAS Number: 100823-03-8
Molecular Formula: C₂₀H₂₂N₂O₂
Molecular Weight: 322.40100
Catalog: Signaling Pathways Apoptosis Bcl-2 Family
Create Date: 2017-01-19 04:15:00
Modify Date: 2026-07-16 18:01:05
TC11 is a MCL1 degradator and Caspase-9 and CDK1 activator. TC11 structurally relates to immunomodulatory drugs as phenylphthalimide derivative. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest[1][2].

Name	5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione
Synonyms	1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl]-TC11 CLT-003 TC11 CLT-003 1H-Isoindole-1,3(2H)-dione, 5-amino-2-[2,6-bis(1-methylethyl)phenyl] Cyclin dendent kinase,Apoptotic,Mitotic,Inhibitor,Immunomodulatory,Derivative,inhibit,CDK,TC-11,Bcl-2 Family,TC 11,Antitumor,TC11,Phenylphthalimide,Death,Caspase 5-Amino-2-(2,6-diisopropylphenyl)isoindoline-1,3-dione TC11, 10 mM in DMSO 1H-Isoindole-1,3(2H)-dione,5-amino-2-[2,6-bis(1-methylethyl)phenyl] 2-(2,6-Diisopropylphenyl)-5-amino-1H-isoindole-1,3-dione

Description	TC11 is a MCL1 degradator and Caspase-9 and CDK1 activator. TC11 structurally relates to immunomodulatory drugs as phenylphthalimide derivative. TC11 induces apoptotic death caused by degradation of MCL1 during prolonged mitotic arrest[1][2].
Related Catalog	Signaling Pathways >> Apoptosis >> Bcl-2 Family Research Areas >> Cancer Signaling Pathways >> Apoptosis >> Caspase Signaling Pathways >> Cell Cycle/DNA Damage >> CDK
Target	CDK1 Caspase-9 MCL1
In Vitro	Cell Viability Assay[1] Cell Line: KMS34 cells Concentration: 0~30 μM Incubation Time: 24 hours Result: Induced cell death. Western Blot Analysis[1] Cell Line: KMS34 cells Concentration: 5 μM Incubation Time: 0~48 hours Result: Induced cell death occurs through an apoptotic pathway and downregulated MCL1 expression. Cell Cycle Analysis[1] Cell Line: KMS34 cells Concentration: 5 μM Incubation Time: 24 hours Result: Induced M arrest.
In Vivo	TC11 (0~30 μM; 24 hours; KMS34 cells) induces cell death in KMS34[1]. TC11 (5 μM; 0~48 hours; KMS34 cells) induces cell death occurs through an apoptotic pathway and downregulates MCL1 expression[1]. TC11 (5 μM; 24 hours; KMS34 cells) induces M arrest[1].
References	[1]. Ichikawa D, et al. A phenylphthalimide derivative, TC11, induces apoptosis by degrading MCL1 in multiple myeloma cells. Biochem Biophys Res Commun. 2020;521(1):252-258. [2]. Shiheido H, et al. A phthalimide derivative that inhibits centrosomal clustering is effective on multiple myeloma. PLoS One. 2012;7(6):e38878.

Molecular Formula	C₂₀H₂₂N₂O₂
Molecular Weight	322.40100
Exact Mass	322.16800
PSA	63.40000
LogP	4.96240
Storage condition	2-8°C

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