1160247-92-6
1160247-92-6 structure
- Name: VU 0238429
- Chemical Name: 1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
- CAS Number: 1160247-92-6
- Molecular Formula: C17H12F3NO4
- Molecular Weight: 351.27700
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2016-11-19 11:58:22
- Modify Date: 2024-01-09 17:32:51
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VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.
| Name | 1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione |
|---|---|
| Synonyms | 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione |
| Description | VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM. |
|---|---|
| Related Catalog | |
| Target |
EC50: 1.16 μM (mAChR5)[1]. |
| In Vitro | VU 0238429 is positive allosteric modulator of mAChR5 (M5), with an EC50 of 1.16 μM, >30-fold selectivity versus M1 and M3, with no M2 or M4 potentiator activity[1]. |
| References |
| Molecular Formula | C17H12F3NO4 |
|---|---|
| Molecular Weight | 351.27700 |
| Exact Mass | 351.07200 |
| PSA | 55.84000 |
| LogP | 3.38830 |
| Storage condition | 2-8℃ |
| Symbol |
GHS07, GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319-H400 |
| Precautionary Statements | P273-P305 + P351 + P338 |
| RIDADR | UN 3077 9 / PGIII |
|
~10%
1160247-92-6 |
| Literature: Bridges, Thomas M.; Marlo, Joy E.; Niswender, Colleen M.; Jones, Carrie K.; Jadhav, Satyawan B.; Gentry, Patrick R.; Plumley, Hyekyung C.; Weaver, C. David; Conn, P. Jeffrey; Lindsley, Craig W. Journal of Medicinal Chemistry, 2009 , vol. 52, # 11 p. 3445 - 3448 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |