197801-88-0

197801-88-0 structure

Name: SN 003
Chemical Name: 1-(1-Methoxy-2-butanyl)-N-(4-methoxy-2-methylphenyl)-6-methyl-1H- [1,2,3]triazolo[4,5-c]pyridin-4-amine
CAS Number: 197801-88-0
Molecular Formula: C₁₉H₂₅N₅O₂
Molecular Weight: 355.43400
Catalog: Signaling Pathways GPCR/G Protein CRFR
Create Date: 2017-07-27 01:13:32
Modify Date: 2024-04-08 19:18:56
SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat[1][2][3].

Name	1-(1-Methoxy-2-butanyl)-N-(4-methoxy-2-methylphenyl)-6-methyl-1H- [1,2,3]triazolo[4,5-c]pyridin-4-amine

Description	SN003 is a reversible antagonist of corticotropin releasing factor receptor 1 (CRFR 1) (IC50 = 241 nM) that displays more than 1000-fold selectivity over CRFR 2. SN003 suppresses CRF-induced ACTH release in vitro. SN003 attenuates depressive-like behavior in rat[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CRFR Research Areas >> Neurological Disease
References	[1]. J S Dileep Kumar, et al. Synthesis and in vivo evaluation of [11C]SN003 as a PET ligand for CRF1 receptors. Bioorg Med Chem. 2006 Jun 15;14(12):4029-34. [2]. Andrzej Wróbel, et al. Inhibition of the CRF1 receptor influences the activity of antidepressant drugs in the forced swim test in rats. Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug;390(8):769-774. [3]. Simeon J Ramsey, et al. Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo. Br J Pharmacol. 2011 Oct;164(3):992-1007.