439861-56-0

439861-56-0 structure

Name: NPY 5RA972
Chemical Name: N-(4-methyl-9-propan-2-ylcarbazol-3-yl)morpholine-4-carboxamide
CAS Number: 439861-56-0
Molecular Formula: C₂₁H₂₅N₃O₂
Molecular Weight: 351.44200
Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
Create Date: 2016-02-10 08:38:33
Modify Date: 2024-02-25 12:40:04
NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor[1].

Name	N-(4-methyl-9-propan-2-ylcarbazol-3-yl)morpholine-4-carboxamide
Synonyms	n-[4-methyl-9-(1-methylethyl)-9h-carbazol-3-yl]-4-morpholinecarboxamide

Description	NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
In Vivo	NPY5RA-972(p.o., 10.5 mg/kg) 在大鼠中的 Tmax 值为 1 小时，此时 Cmax 为 35 μM，半衰期为 6.4 小时，且即使在给药后 24 小时总血浆浓度仍大于3 μM/h[1]。 NPY5RA-972 (p.o., 1-10 mg/kg) 抑制了由选择性 NPY Y5 受体激动剂引起的食物摄入，但对自由喂养的 Wistar 大鼠或膳食肥胖大鼠的摄食量或体重均无影响[1]。
References	[1]. Andrew V Turnbull, et al. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. 2002 Aug;51(8):2441-9.