NPY 5RA972
Modify Date: 2024-02-25 12:40:04
NPY 5RA972 structure
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Common Name | NPY 5RA972 | ||
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| CAS Number | 439861-56-0 | Molecular Weight | 351.44200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H25N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NPY 5RA972NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor[1]. |
| Name | N-(4-methyl-9-propan-2-ylcarbazol-3-yl)morpholine-4-carboxamide |
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| Synonym | More Synonyms |
| Description | NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor[1]. |
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| Related Catalog | |
| In Vivo | NPY5RA-972(p.o., 10.5 mg/kg) 在大鼠中的 Tmax 值为 1 小时，此时 Cmax 为 35 μM，半衰期为 6.4 小时，且即使在给药后 24 小时总血浆浓度仍大于3 μM/h[1]。 NPY5RA-972 (p.o., 1-10 mg/kg) 抑制了由选择性 NPY Y5 受体激动剂引起的食物摄入，但对自由喂养的 Wistar 大鼠或膳食肥胖大鼠的摄食量或体重均无影响[1]。 |
| References |
| Molecular Formula | C21H25N3O2 |
|---|---|
| Molecular Weight | 351.44200 |
| Exact Mass | 351.19500 |
| PSA | 49.99000 |
| LogP | 4.49940 |
| n-[4-methyl-9-(1-methylethyl)-9h-carbazol-3-yl]-4-morpholinecarboxamide |