NPY 5RA972

Modify Date: 2026-07-01 06:39:19

NPY 5RA972 structure	Common Name	NPY 5RA972
	CAS Number	439861-56-0	Molecular Weight	351.44200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₁H₂₅N₃O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NPY 5RA972

NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor[1].

Name	N-(4-methyl-9-propan-2-ylcarbazol-3-yl)morpholine-4-carboxamide
Synonym	More Synonyms

Description	NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neuropeptide Y Receptor
In Vivo	NPY5RA-972(p.o., 10.5 mg/kg) 在大鼠中的 Tmax 值为 1 小时，此时 Cmax 为 35 μM，半衰期为 6.4 小时，且即使在给药后 24 小时总血浆浓度仍大于3 μM/h[1]。 NPY5RA-972 (p.o., 1-10 mg/kg) 抑制了由选择性 NPY Y5 受体激动剂引起的食物摄入，但对自由喂养的 Wistar 大鼠或膳食肥胖大鼠的摄食量或体重均无影响[1]。
References	[1]. Andrew V Turnbull, et al. Selective antagonism of the NPY Y5 receptor does not have a major effect on feeding in rats. Diabetes. 2002 Aug;51(8):2441-9.

Molecular Formula	C₂₁H₂₅N₃O₂
Molecular Weight	351.44200
Exact Mass	351.19500
PSA	49.99000
LogP	4.49940
InChIKey	ZNFMHLDBJPAFEQ-UHFFFAOYSA-N
SMILES	Cc1c(NC(=O)N2CCOCC2)ccc2c1c1ccccc1n2C(C)C

Name: Binding affinity to the human Neuropeptide Y receptor Y5 (NPY5)
Source: ChEMBL
Target: Neuropeptide Y receptor type 5
External Id: CHEMBL755166

Name: Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
Source: NCGC
External Id: IP6K1-p1

Name: Bioavailability of compound at a dose 30 umol/kg administered orally
Source: ChEMBL
Target: N/A
External Id: CHEMBL637853

Name: Clearance level at a dose 10 umol/kg administered intravenously
Source: ChEMBL
Target: N/A
External Id: CHEMBL634498

Name: Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
Source: NCGC
External Id: CYP3A4437

Name: Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2D6395

Name: Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit...
Source: ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
Target: N/A
External Id: HMS1315

Name: ASTRAZENECA: Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake fl...
Source: ChEMBL
Target: N/A
External Id: CHEMBL3301363

Name: Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu...
Source: NCGC
External Id: CYP2C9536

Name: SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f...
Source: ChEMBL
Target: Replicase polyprotein 1ab
External Id: CHEMBL4495582

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n-[4-methyl-9-(1-methylethyl)-9h-carbazol-3-yl]-4-morpholinecarboxamide

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Shanghai Nianxing Industrial Co., Ltd
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Product Name: NPY5RA972
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Purity: 98.0%
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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.