619331-12-3

619331-12-3 structure

Name: BMS-585248
Chemical Name: 1-(4-benzoylpiperazin-1-yl)-2-[4-fluoro-7-(triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione
CAS Number: 619331-12-3
Molecular Formula: C₂₂H₁₈FN₇O₃
Molecular Weight: 447.42200
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2016-03-07 03:05:05
Modify Date: 2024-01-10 17:33:00
BMS-585248 is a potent, third-generation HIV-1 attachment inhibitor with a promising initial in vitro and in vivo pharmacokinetic profile[1].

Name	1-(4-benzoylpiperazin-1-yl)-2-[4-fluoro-7-(triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione
Synonyms	unii-cio2tzz9h1

Description	BMS-585248 is a potent, third-generation HIV-1 attachment inhibitor with a promising initial in vitro and in vivo pharmacokinetic profile[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1
In Vivo	BMS-585248 (静脉注射 (1 mg/kg) 和口服 (5-200 mg/kg); 一次)具有良好的药代动力学特征，雄性大鼠静脉注射 (1mg /kg) 和口服 (5mg /kg) 后，AUC 值分别为 3220 nM·h 和 8064 nM·h。 Animal Model: Male rats[1] Dosage: 5, 15, and 200 mg/kg Administration: Orally, once (Pharmacokinetic Analysis) Result: Pharmacokinetic Parameters of BMS-585248 in male rats[1]. PO Dose (mg/kg) 15 75 200 Cmax (μM) 6.6 8.4 11 AUCtot (μM·h) 42 115 145
References	[1]. Regueiro-Ren A, et al. Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment 13. Synthesis and profiling of a novel amminium prodrug of the HIV-1 attachment inhibitor BMS-585248. J Med Chem. 2013 Feb 28;56(4):1670-6.