BMS-585248
Modify Date: 2025-10-09 17:51:47
BMS-585248 structure
|
Common Name | BMS-585248 | ||
|---|---|---|---|---|
| CAS Number | 619331-12-3 | Molecular Weight | 447.42200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H18FN7O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BMS-585248BMS-585248 is a potent, third-generation HIV-1 attachment inhibitor with a promising initial in vitro and in vivo pharmacokinetic profile[1]. |
| Name | 1-(4-benzoylpiperazin-1-yl)-2-[4-fluoro-7-(triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]ethane-1,2-dione |
|---|---|
| Synonym | More Synonyms |
| Description | BMS-585248 is a potent, third-generation HIV-1 attachment inhibitor with a promising initial in vitro and in vivo pharmacokinetic profile[1]. |
|---|---|
| Related Catalog | |
| Target |
HIV-1 |
| In Vivo | BMS-585248 (静脉注射 (1 mg/kg) 和口服 (5-200 mg/kg); 一次)具有良好的药代动力学特征，雄性大鼠静脉注射 (1mg /kg) 和口服 (5mg /kg) 后，AUC 值分别为 3220 nM·h 和 8064 nM·h。 Animal Model: Male rats[1] Dosage: 5, 15, and 200 mg/kg Administration: Orally, once (Pharmacokinetic Analysis) Result: Pharmacokinetic Parameters of BMS-585248 in male rats[1]. PO Dose (mg/kg) 15 75 200 Cmax (μM) 6.6 8.4 11 AUCtot (μM·h) 42 115 145 |
| References |
| Molecular Formula | C22H18FN7O3 |
|---|---|
| Molecular Weight | 447.42200 |
| Exact Mass | 447.14600 |
| PSA | 117.08000 |
| LogP | 1.32580 |
| InChIKey | YILIMUKOYIOIAY-UHFFFAOYSA-N |
| SMILES | O=C(C(=O)N1CCN(C(=O)c2ccccc2)CC1)c1c[nH]c2c(-n3ccnn3)ncc(F)c12 |
|
Name: Permeability across human Caco2 cells
Source: ChEMBL
Target: Caco-2
External Id: CHEMBL2341352
|
|
Name: Clearance in human liver microsomes
Source: ChEMBL
Target: Liver microsomes
External Id: CHEMBL2341351
|
|
Name: Oral bioavailability in rat at 5 mg/kg
Source: ChEMBL
Target: Rattus norvegicus
External Id: CHEMBL2341350
|
|
Name: Clearance in rat liver microsomes
Source: ChEMBL
Target: Liver microsomes
External Id: CHEMBL2341349
|
|
Name: Antiviral activity against HIV1 JRFL infected in human HeLa67 cells after 3 days by s...
Source: ChEMBL
Target: Human immunodeficiency virus 1
External Id: CHEMBL2341834
|
|
Name: Antiviral activity against HIV1 BRU infected in MT2 cells after 4 to 5 days by revers...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL2341344
|
|
Name: Antiviral activity against HIV1 BRU infected in MT2 cells after 4 to 5 days by revers...
Source: ChEMBL
Target: NON-PROTEIN TARGET
External Id: CHEMBL2341343
|
|
Name: Ratio of EC50 for HIV1 BRU in presence of human serum to EC50 for HIV1 BRU in absence...
Source: ChEMBL
Target: N/A
External Id: CHEMBL2341342
|
|
Name: Plasma protein binding in human at 1 ug/ml by ultrafiltration method
Source: ChEMBL
Target: Plasma
External Id: CHEMBL2341341
|
Total 54, Current Page 1 of 6
1
2
3
4
5
| unii-cio2tzz9h1 |