951393-55-8

951393-55-8 structure

Name: Trandolaprilat Monohydrate
Chemical Name: Trandolaprilat Monohydrate
CAS Number: 951393-55-8
Molecular Formula: C₂₂H₃₂N₂O₆
Molecular Weight: 420.49900
Catalog: Signaling Pathways Metabolic Enzyme/Protease Angiotensin-converting Enzyme (ACE)
Create Date: 2018-05-02 08:00:00
Modify Date: 2024-02-12 10:16:59
Trandolaprilate hydrate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate hydrate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[1][2].

Name	Trandolaprilat Monohydrate
Synonyms	(2S,3aR,7aS)-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid, hydrate Trandolaprilate Monohydrate

Description	Trandolaprilate hydrate is a potent angiotensin-converting enzyme (ACE) inhibitor. Trandolaprilate hydrate partially inhibits angiotensin-I-mediated c-fos induction. Trandolaprilate is main bioactive metabolite of Trandolapril. Trandolaprilate shows high lipophilicity[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)
Target	Human Endogenous Metabolite
References	[1]. Al-Hawash LA, et al. Stability-indicating HPLC determination of trandolapril in bulk drug and pharmaceutical dosage forms. Int J Anal Chem. 2015;2015:820517. [2]. Millet D, et al. Effects of angiotensins on cellular hypertrophy and c-fos expression in cultured arterial smooth muscle cells. Eur J Biochem. 1992 Jun 1;206(2):367-72.