Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 5-hydroxy-2-(1'-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

123297-90-5

123297-90-5 structure

Name: 5-hydroxy-2-(1'-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione
Chemical Name: 5-hydroxy-2-(1'-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione
CAS Number: 123297-90-5
Molecular Formula: C₁₄H₁₀O₅
Molecular Weight: 258.22600
Catalog: Signaling Pathways JAK/STAT Signaling STAT
Create Date: 2016-05-12 04:59:13
Modify Date: 2024-04-02 20:46:07
STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3[1].

Name	5-hydroxy-2-(1'-hydroxyethyl)naphtho[2,3-b]furan-4,9-dione
Synonyms	(-)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furane-4,9-dione (+/-)-2-(1-hydroxyethyl)-5-hydroxynaphtho[2,3-b]furan-4,9-dione 5-hydroxy-2-(1-hydroxyethyl)benzo[f][1]benzofuran-4,9-dione SERRATIFOLIOL

Description	STAT3-IN-14 (Compound 1) is a STAT3 inhibitor and has STAT3 phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region of STAT3[1].
Related Catalog	Signaling Pathways >> Stem Cell/Wnt >> STAT Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> STAT
Target	IC50: 0.42 μM (MDA-MB-231); 0.50 μM (MCF7); 0.13 μM (A549) [1]
In Vitro	STAT3-IN-14 (Compound 1) shows inhibitory activity against phosphor-STAT3. STAT3-IN-14 (Compound 1) reduces the phosphorylation inhibitory activity against MDA-MB-231 cells (JAK/STAT pathway constitutively active) in does dependent manner, but no inhibitory activities against JAK kinases. STAT3-IN-14 (Compound 1) has growth inhibitory activity with with IC50 values of 0.42 μM, 0.50 μM and 0.13 μM in MDA-MB-231, MCF7 and A549cells, respectively[1]. Western Blot Analysis[1] Cell Line: MCF7 cells; MDA-MB-231 cells Concentration: 1 or 10 μM; 0.5, 1, 2, 4 μM Incubation Time: 1 h; 2 h Result: Completely inhibited STAT3 phosphorylation at 10 μM, and partial inhibition at 1 μM. Reduced the phosphorylation of STAT3 in does dependent manner. Cell Proliferation Assay[1] Cell Line: MDA-MB-231, MCF7 and A549 cells Concentration: 0-30 μM Incubation Time: 72 h Result: Showed moderate to strong growth inhibitory activity among the three cancer cell lines.
References	[1]. Teruyuki Tahara, et al. STAT3 inhibitory activity of naphthoquinones isolated from Tabebuia avellanedae. Bioorg Med Chem. 2020 Mar 15;28(6):115347.

Density	1.506g/cm3
Boiling Point	465ºC at 760 mmHg
Molecular Formula	C₁₄H₁₀O₅
Molecular Weight	258.22600
Flash Point	235ºC
Exact Mass	258.05300
PSA	87.74000
LogP	1.81390
Vapour Pressure	1.91E-09mmHg at 25°C
Index of Refraction	1.668

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