99534-03-9

99534-03-9 structure

Name: PKI (5-24)
Chemical Name: h-thr-thr-tyr-ala-asp-phe-ile-ala-ser-gly-arg-thr-gly-arg-arg-asn-ala-ile-his-asp-oh
CAS Number: 99534-03-9
Molecular Formula: C₉₄H₁₄₈N₃₂O₃₁
Molecular Weight: 2222.38000
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK PKA
Create Date: 2018-04-24 08:00:00
Modify Date: 2024-01-02 17:38:59
PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2].

Name	h-thr-thr-tyr-ala-asp-phe-ile-ala-ser-gly-arg-thr-gly-arg-arg-asn-ala-ile-his-asp-oh
Synonyms	PROTEIN KINASE INHIBITOR RABBIT ip20 TTYADFIASGRTGRRNAIHD PROTEIN KINASE A INHIBITOR 5-24 protein kinase inhibitor from rabbit H-TTYADFIASGRTGRRNAIHD

Description	PKI(5-24) is a potent, competitive, and synthetic peptide inhibitor of PKA (cAMP-dependent protein kinase), with a Ki of 2.3 nM. PKI(5-24) corresponds to residues 5-24 in the naturally occurring heat-stable protein kinase inhibitor[1][2].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> PKA Research Areas >> Others Signaling Pathways >> Stem Cell/Wnt >> PKA
In Vitro	PKI(5-24) is a 20-residue peptide has been synthesized that corresponds to the active site of the skeletal muscle inhibitor protein[1]. PKI(5-24) inhibits phosphotransferase activity of the mutant cGMP kinase with higher potency than that of wild type, with Ki values of 42 μΜ and 160 μΜ, respectively[2].
References	[1]. Cheng HC, et al. A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem. 1986;261(3):989-992. [2]. Ruth P, et al F. A cGMP kinase mutant with increased sensitivity to the protein kinase inhibitor peptide PKI(5-24). Biol Chem. 1996;377(7-8):513-520.

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